Change in cell shape is required for matrix metalloproteinase-induced epithelial-mesenchymal transition of mammary epithelial cells Page: 1 of 26
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Change in cell shape is required for matrix metalloproteinase-induced epithelial-
mesenchymal transition of mammary epithelial cells
Celeste M. Nelson ,2,*, Davitte Khauv3, Mina J. Bissell, & Derek C. Radisky3'*
1Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720
2Chemical Engineering, Princeton University, Princeton, NJ 08544
3Cancer Biology, Mayo Clinic Cancer Center, Jacksonville, FL 32224
*Correspondence to Celeste M. Nelson (celestengprinceton.edu) and Derek C. Radisky
Running head: MMP3-induced EMT requires altered cell shape.
Keywords: Cell morphology; cell spreading; matrix metalloproteinase; epithelial-
mesenchymal transition; Raclb; TGFO; micropatterned substrata; mammary epithelial
cells; reactive oxygen species
Number of figures: 5
Abbreviations: EMT, epithelial-mesenchymal transition; MMP, matrix metalloproteinase;
TGF-(3, transforming growth factor-0; NAC, N-acetyl cysteine; ROS, reactive oxygen
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Nelson, Celeste M.; Khauv, Davitte; Bissell, Mina J. & Radisky, Derek C. Change in cell shape is required for matrix metalloproteinase-induced epithelial-mesenchymal transition of mammary epithelial cells, article, June 26, 2008; Berkeley, California. (digital.library.unt.edu/ark:/67531/metadc901999/m1/1/: accessed December 13, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.