Unraveling the microenvironmental influences on the normal mammary gland and induction and progression of breast cancer

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The normal mammary gland and invasive breast cancer are both complex 'organs' composed of multiple cell types as well as extracellular matrix (ECM) in three-dimensional (3D) space. Conventionally, both normal and malignant breast cells are studied in vitro as two-dimensional (2D) monolayers of epithelial cells, which results in the loss of structure and tissue function. Many laboratories are now investigating regulation of signaling function in normal mammary gland using 3D cultures. However, it is important also to assay malignant breast cells ex vivo in a physiologically relevant environment to more closely mimic tumor architecture, signal transduction regulation and tumor behavior ... continued below

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Weigelt, Britta & Bissell, Mina J. June 26, 2008.

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Description

The normal mammary gland and invasive breast cancer are both complex 'organs' composed of multiple cell types as well as extracellular matrix (ECM) in three-dimensional (3D) space. Conventionally, both normal and malignant breast cells are studied in vitro as two-dimensional (2D) monolayers of epithelial cells, which results in the loss of structure and tissue function. Many laboratories are now investigating regulation of signaling function in normal mammary gland using 3D cultures. However, it is important also to assay malignant breast cells ex vivo in a physiologically relevant environment to more closely mimic tumor architecture, signal transduction regulation and tumor behavior in vivo. Here we present the potential of these 3D models for drug testing, target validation and guidance of patient selection for clinical trials. We argue also that in order to get full insight into the biology of the normal and malignant breast, and to create in vivo-like models for therapeutic approaches in humans, we need to continue to create more complex heterotypic models to approach the full context the cells encounter in the human body.

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  • Journal Name: Seminars in Cancer Biology; Journal Volume: 18; Journal Issue: 5; Related Information: Journal Publication Date: Oct. 2008

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  • Report No.: LBNL-798E
  • Grant Number: DE-AC02-05CH11231
  • DOI: 10.1016/j.semcancer.2008.03.013 | External Link
  • Office of Scientific & Technical Information Report Number: 944977
  • Archival Resource Key: ark:/67531/metadc901981

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Office of Scientific & Technical Information Technical Reports

Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

Office of Scientific and Technical Information (OSTI) is the Department of Energy (DOE) office that collects, preserves, and disseminates DOE-sponsored research and development (R&D) results that are the outcomes of R&D projects or other funded activities at DOE labs and facilities nationwide and grantees at universities and other institutions.

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  • June 26, 2008

Added to The UNT Digital Library

  • Sept. 27, 2016, 1:39 a.m.

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  • Oct. 3, 2016, 2:23 p.m.

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Weigelt, Britta & Bissell, Mina J. Unraveling the microenvironmental influences on the normal mammary gland and induction and progression of breast cancer, article, June 26, 2008; Berkeley, California. (digital.library.unt.edu/ark:/67531/metadc901981/: accessed April 24, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.