Tools for characterizing biomembranes : final LDRD report.

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A suite of experimental nuclear magnetic resonance (NMR) spectroscopy tools were developed to investigate lipid structure and dynamics in model membrane systems. By utilizing both multinuclear and multidimensional NMR experiments a range of different intra- and inter-molecular contacts were probed within the membranes. Examples on pure single component lipid membranes and on the canonical raft forming mixture of DOPC/SM/Chol are presented. A unique gel phase pretransition in SM was also identified and characterized using these NMR techniques. In addition molecular dynamics into the hydrogen bonding network unique to sphingomyelin containing membranes were evaluated as a function of temperature, and are ... continued below

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164 p.

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Alam, Todd Michael; Stevens, Mark; Holland, Gregory P. & McIntyre, Sarah K. October 1, 2007.

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A suite of experimental nuclear magnetic resonance (NMR) spectroscopy tools were developed to investigate lipid structure and dynamics in model membrane systems. By utilizing both multinuclear and multidimensional NMR experiments a range of different intra- and inter-molecular contacts were probed within the membranes. Examples on pure single component lipid membranes and on the canonical raft forming mixture of DOPC/SM/Chol are presented. A unique gel phase pretransition in SM was also identified and characterized using these NMR techniques. In addition molecular dynamics into the hydrogen bonding network unique to sphingomyelin containing membranes were evaluated as a function of temperature, and are discussed.

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164 p.

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  • Report No.: SAND2007-6547
  • Grant Number: AC04-94AL85000
  • DOI: 10.2172/934587 | External Link
  • Office of Scientific & Technical Information Report Number: 934587
  • Archival Resource Key: ark:/67531/metadc901724

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  • October 1, 2007

Added to The UNT Digital Library

  • Sept. 27, 2016, 1:39 a.m.

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  • Dec. 7, 2016, 11:13 p.m.

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Alam, Todd Michael; Stevens, Mark; Holland, Gregory P. & McIntyre, Sarah K. Tools for characterizing biomembranes : final LDRD report., report, October 1, 2007; United States. (digital.library.unt.edu/ark:/67531/metadc901724/: accessed October 19, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.