An Appreciation of the Scientific Life and Acheivements of Bruce Merrifield

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Bruce Merrifield's scientific biography, 'Life During a Golden Age of Peptide Chemistry: The Concept and Development of Solid-Phase Peptide Synthesis', provides a history of solid phase-peptide synthesis (SPPS) from 1959 to 1993 [1]. While many readers will be familiar with SPPS literature after 1963, the inclusion of unpublished material from Merrifield's early laboratory notebooks opens a fascinating window on the development of SPPS from the formulation of concept in 1959 (p. 56, ref. 1) to the synthesis of a tetrapeptide four years later [2]. This early period was characterized by slow progress interrupted by numerous setbacks that led Bruce to ... continued below

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5 p. (0.1 MB)

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Mitchell, R June 15, 2007.

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Bruce Merrifield's scientific biography, 'Life During a Golden Age of Peptide Chemistry: The Concept and Development of Solid-Phase Peptide Synthesis', provides a history of solid phase-peptide synthesis (SPPS) from 1959 to 1993 [1]. While many readers will be familiar with SPPS literature after 1963, the inclusion of unpublished material from Merrifield's early laboratory notebooks opens a fascinating window on the development of SPPS from the formulation of concept in 1959 (p. 56, ref. 1) to the synthesis of a tetrapeptide four years later [2]. This early period was characterized by slow progress interrupted by numerous setbacks that led Bruce to later record (p. 90, ref. 1): 'At the end of the first two years the results were so poor, I wonder what made me think that this approach would ever succeed; but from the outset I had a strong conviction that this was a good idea, and I am glad that I stayed with it long enough'. Garland Marshall, Bruce's first graduate student (1963-1966), as well as later colleagues, were essentially unaware of the many highways, byways and dead ends that Bruce had explored in the early years [3].

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5 p. (0.1 MB)

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  • Presented at: An Appreciation of the Scientific Life and Acheivements of Bruce Merrifield, Montreal, Canada, Jun 26 - Jun 30, 2007

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  • Report No.: UCRL-PROC-231884
  • Grant Number: W-7405-ENG-48
  • Office of Scientific & Technical Information Report Number: 920495
  • Archival Resource Key: ark:/67531/metadc899586

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Office of Scientific & Technical Information Technical Reports

Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

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  • June 15, 2007

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  • Sept. 27, 2016, 1:39 a.m.

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  • April 13, 2017, 6:07 p.m.

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Mitchell, R. An Appreciation of the Scientific Life and Acheivements of Bruce Merrifield, article, June 15, 2007; Livermore, California. (digital.library.unt.edu/ark:/67531/metadc899586/: accessed September 25, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.