Using Non-Invasive Multi-Spectral Imaging to Quantitatively Assess Tissue Vasculature

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This research describes a non-invasive, non-contact method used to quantitatively analyze the functional characteristics of tissue. Multi-spectral images collected at several near-infrared wavelengths are input into a mathematical optical skin model that considers the contributions from different analytes in the epidermis and dermis skin layers. Through a reconstruction algorithm, we can quantify the percent of blood in a given area of tissue and the fraction of that blood that is oxygenated. Imaging normal tissue confirms previously reported values for the percent of blood in tissue and the percent of blood that is oxygenated in tissue and surrounding vasculature, for the ... continued below

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Vogel, A; Chernomordik, V; Riley, J; Hassan, M; Amyot, F; Dasgeb, B et al. October 4, 2007.

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Description

This research describes a non-invasive, non-contact method used to quantitatively analyze the functional characteristics of tissue. Multi-spectral images collected at several near-infrared wavelengths are input into a mathematical optical skin model that considers the contributions from different analytes in the epidermis and dermis skin layers. Through a reconstruction algorithm, we can quantify the percent of blood in a given area of tissue and the fraction of that blood that is oxygenated. Imaging normal tissue confirms previously reported values for the percent of blood in tissue and the percent of blood that is oxygenated in tissue and surrounding vasculature, for the normal state and when ischemia is induced. This methodology has been applied to assess vascular Kaposi's sarcoma lesions and the surrounding tissue before and during experimental therapies. The multi-spectral imaging technique has been combined with laser Doppler imaging to gain additional information. Results indicate that these techniques are able to provide quantitative and functional information about tissue changes during experimental drug therapy and investigate progression of disease before changes are visibly apparent, suggesting a potential for them to be used as complementary imaging techniques to clinical assessment.

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PDF-file: 32 pages; size: 0.2 Mbytes

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  • Journal Name: Journal of Biomedical Optics, vol. 12, no. 5, November 1, 2007, pp. 051604; Journal Volume: 12; Journal Issue: 5

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  • Report No.: UCRL-JRNL-235502
  • Grant Number: W-7405-ENG-48
  • Office of Scientific & Technical Information Report Number: 943806
  • Archival Resource Key: ark:/67531/metadc899373

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Office of Scientific & Technical Information Technical Reports

Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

Office of Scientific and Technical Information (OSTI) is the Department of Energy (DOE) office that collects, preserves, and disseminates DOE-sponsored research and development (R&D) results that are the outcomes of R&D projects or other funded activities at DOE labs and facilities nationwide and grantees at universities and other institutions.

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  • October 4, 2007

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  • Sept. 27, 2016, 1:39 a.m.

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  • Dec. 2, 2016, 6:01 p.m.

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Vogel, A; Chernomordik, V; Riley, J; Hassan, M; Amyot, F; Dasgeb, B et al. Using Non-Invasive Multi-Spectral Imaging to Quantitatively Assess Tissue Vasculature, article, October 4, 2007; Livermore, California. (digital.library.unt.edu/ark:/67531/metadc899373/: accessed December 17, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.