Haloarchaeal Protein Translocation via the Twin Arginine Translocation Pathway

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Protein transport across hydrophobic membranes that partition cellular compartments is essential in all cells. The twin arginine translocation (Tat) pathway transports proteins across the prokaryotic cytoplasmic membranes. Distinct from the universally conserved Sec pathway, which secretes unfolded proteins, the Tat machinery is unique in that it secretes proteins in a folded conformation, making it an attractive pathway for the transport and secretion of heterologously expressed proteins that are Sec-incompatible. During the past 7 years, the DOE-supported project has focused on the characterization of the diversity of bacterial and archaeal Tat substrates as well as on the characterization of the Tat ... continued below

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Mechthild, Pohlschroder February 3, 2009.

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Protein transport across hydrophobic membranes that partition cellular compartments is essential in all cells. The twin arginine translocation (Tat) pathway transports proteins across the prokaryotic cytoplasmic membranes. Distinct from the universally conserved Sec pathway, which secretes unfolded proteins, the Tat machinery is unique in that it secretes proteins in a folded conformation, making it an attractive pathway for the transport and secretion of heterologously expressed proteins that are Sec-incompatible. During the past 7 years, the DOE-supported project has focused on the characterization of the diversity of bacterial and archaeal Tat substrates as well as on the characterization of the Tat pathway of a model archaeon, Haloferax volcanii, a member of the haloarchaea. We have demonstrated that H. volcanii uses this pathway to transport most of its secretome.

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  • Report No.: DOE-ER15169 1 Final Report
  • Grant Number: FG02-01ER15169
  • DOI: 10.2172/946802 | External Link
  • Office of Scientific & Technical Information Report Number: 946802
  • Archival Resource Key: ark:/67531/metadc899199

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  • February 3, 2009

Added to The UNT Digital Library

  • Sept. 27, 2016, 1:39 a.m.

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  • Nov. 28, 2016, 7:33 p.m.

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Mechthild, Pohlschroder. Haloarchaeal Protein Translocation via the Twin Arginine Translocation Pathway, report, February 3, 2009; United States. (digital.library.unt.edu/ark:/67531/metadc899199/: accessed September 23, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.