Use of ceragenins to create novel biofouling resistant water-treatment membranes.

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Description

Scoping studies have demonstrated that ceragenins, when linked to water-treatment membranes have the potential to create biofouling resistant water-treatment membranes. Ceragenins are synthetically produced molecules that mimic antimicrobial peptides. Evidence includes measurements of CSA-13 prohibiting the growth of and killing planktonic Pseudomonas fluorescens. In addition, imaging of biofilms that were in contact of a ceragenin showed more dead cells relative to live cells than in a biofilm that had not been treated with a ceragenin. This work has demonstrated that ceragenins can be attached to polyamide reverse osmosis (RO) membranes, though work needs to improve the uniformity of the attachment. ... continued below

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32 p.

Creation Information

Hibbs, Michael R.; Altman, Susan Jeanne; Feng, Yanshu (Brigham Young University, Provo, UT); Savage, Paul B. (Brigham Young University, Provo, UT); Pollard, Jacob (Brigham Young University, Provo, UT); Sanchez, Andres L. (LMATA, Albuquerque, NM) et al. December 1, 2008.

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Description

Scoping studies have demonstrated that ceragenins, when linked to water-treatment membranes have the potential to create biofouling resistant water-treatment membranes. Ceragenins are synthetically produced molecules that mimic antimicrobial peptides. Evidence includes measurements of CSA-13 prohibiting the growth of and killing planktonic Pseudomonas fluorescens. In addition, imaging of biofilms that were in contact of a ceragenin showed more dead cells relative to live cells than in a biofilm that had not been treated with a ceragenin. This work has demonstrated that ceragenins can be attached to polyamide reverse osmosis (RO) membranes, though work needs to improve the uniformity of the attachment. Finally, methods have been developed to use hyperspectral imaging with multivariate curve resolution to view ceragenins attached to the RO membrane. Future work will be conducted to better attach the ceragenin to the RO membranes and more completely test the biocidal effectiveness of the ceragenins on the membranes.

Physical Description

32 p.

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  • Report No.: SAND2008-7895
  • Grant Number: AC04-94AL85000
  • DOI: 10.2172/946575 | External Link
  • Office of Scientific & Technical Information Report Number: 946575
  • Archival Resource Key: ark:/67531/metadc898795

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  • December 1, 2008

Added to The UNT Digital Library

  • Sept. 27, 2016, 1:39 a.m.

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  • Dec. 2, 2016, 5:56 p.m.

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Hibbs, Michael R.; Altman, Susan Jeanne; Feng, Yanshu (Brigham Young University, Provo, UT); Savage, Paul B. (Brigham Young University, Provo, UT); Pollard, Jacob (Brigham Young University, Provo, UT); Sanchez, Andres L. (LMATA, Albuquerque, NM) et al. Use of ceragenins to create novel biofouling resistant water-treatment membranes., report, December 1, 2008; United States. (digital.library.unt.edu/ark:/67531/metadc898795/: accessed September 24, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.