Visualization and Analysis of 3D Gene Expression Data

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Recent methods for extracting precise measurements ofspatial gene expression patterns from three-dimensional (3D) image dataopens the way for new analysis of the complex gene regulatory networkscontrolling animal development. To support analysis of this novel andhighly complex data we developed PointCloudXplore (PCX), an integratedvisualization framework that supports dedicated multi-modal, physical andinformation visualization views along with algorithms to aid in analyzingthe relationships between gene expression levels. Using PCX, we helpedour science stakeholders to address many questions in 3D gene expressionresearch, e.g., to objectively define spatial pattern boundaries andtemporal profiles of genes and to analyze how mRNA patterns arecontrolled by their regulatory transcription ... continued below

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Bethel, E. Wes; Rubel, Oliver; Weber, Gunther H.; Hamann, Bernd & Hagen, Hans October 25, 2007.

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Description

Recent methods for extracting precise measurements ofspatial gene expression patterns from three-dimensional (3D) image dataopens the way for new analysis of the complex gene regulatory networkscontrolling animal development. To support analysis of this novel andhighly complex data we developed PointCloudXplore (PCX), an integratedvisualization framework that supports dedicated multi-modal, physical andinformation visualization views along with algorithms to aid in analyzingthe relationships between gene expression levels. Using PCX, we helpedour science stakeholders to address many questions in 3D gene expressionresearch, e.g., to objectively define spatial pattern boundaries andtemporal profiles of genes and to analyze how mRNA patterns arecontrolled by their regulatory transcription factors.

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  • Report No.: LBNL--63658
  • Grant Number: DE-AC02-05CH11231
  • DOI: 10.2172/928239 | External Link
  • Office of Scientific & Technical Information Report Number: 928239
  • Archival Resource Key: ark:/67531/metadc898037

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Office of Scientific & Technical Information Technical Reports

Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

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  • October 25, 2007

Added to The UNT Digital Library

  • Sept. 27, 2016, 1:39 a.m.

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  • Sept. 22, 2017, 3:06 p.m.

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Bethel, E. Wes; Rubel, Oliver; Weber, Gunther H.; Hamann, Bernd & Hagen, Hans. Visualization and Analysis of 3D Gene Expression Data, report, October 25, 2007; Berkeley, California. (digital.library.unt.edu/ark:/67531/metadc898037/: accessed December 15, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.