Development of Oral Fomulation of SCV-07 for Use in Tuberculosis Page: 2 of 10
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DEVELOPMENT OF AN ORAL FORMULATION OF
SCV-07 FOR USE IN TUBERCULOSIS
ISTC Project No 2788
CRADA # ORNL 03-0676
Participant: SciClone Pharmaceuticals
ABSTRACT
An evaluation of the immunomodulatory peptide SCV-07 was conducted as a
possible therapeutic treatment for tuberculosis. This evaluation included mouse models,
clinical trials and various forms of the drug such as liquid injection and development of
an oral pill. It was found that SCV-07 significantly increased the survival rate of animals
infected with lethal doses of Mycobacterium bovis. It enhanced the functional activity of
macrophages in a dose-dependant fashion. The combination of SCV-07 with
bacteriostatic drugs, such as izoniazid, was particularly effective. Phase II clinical trials
in a TB clinic demonstrated that the usage of the injection form of SCV-07 for lung TB
treatment in combination with standard chemotherapy decreased the quantity of patients
with positive sputum assays for Mycobacteria, promoted healing of cavities in lungs,
stabilized parameters of cell immunity, and resulted in a significant improvement in the
general condition of patients. Clinical trial results of the oral drug form are still being
evaluated.
OBJECTIVE
The general objective of this research project is the development and evaluation
of the therapeutic potential of oral drug forms of the immunomodulatory peptide SCV-07
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Development of Oral Fomulation of SCV-07 for Use in Tuberculosis, report, November 16, 2007; Oak Ridge, Tennessee. (https://digital.library.unt.edu/ark:/67531/metadc897775/m1/2/: accessed April 25, 2024), University of North Texas Libraries, UNT Digital Library, https://digital.library.unt.edu; crediting UNT Libraries Government Documents Department.