Use of Microarray Test Data for Toxicogenomic Prediction-Multi-Intelligent Systems for Toxicogenomic Applications (MISTA)

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The YAHSGS LLC and Oak Ridge National Laboratory established a CRADA to develop a computational neural network and wavelets software to facilitate providing national needs for toxicity prediction and overcome the voracious drain of resources (money and time) being directed to the development of pharmaceutical agents. The research project was supported through a STTR Phase I task by NIEHS in 2004. The research deploys state-of-the-art computational neural networks and wavelets to make toxicity prediction on three independent bases: (1) quantitative structure-activity relationships, (2) microarray data, and (3) Massively Parallel Signature Sequencing technology. Upon completion of Phase I, a prototype software ... continued below

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148 Kb

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Wasson, J.S. & Lu, P.-Y. September 12, 2005.

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Description

The YAHSGS LLC and Oak Ridge National Laboratory established a CRADA to develop a computational neural network and wavelets software to facilitate providing national needs for toxicity prediction and overcome the voracious drain of resources (money and time) being directed to the development of pharmaceutical agents. The research project was supported through a STTR Phase I task by NIEHS in 2004. The research deploys state-of-the-art computational neural networks and wavelets to make toxicity prediction on three independent bases: (1) quantitative structure-activity relationships, (2) microarray data, and (3) Massively Parallel Signature Sequencing technology. Upon completion of Phase I, a prototype software Multi-Intelligent System for Toxicogenomic and Applications (MISTA) was developed, the utility's feasibility was demonstrated, and a Phase II proposal was jointly prepared and submitted to NIEHS for funding evaluation. The goals and objectives of the program have been achieved.

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148 Kb

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  • Report No.: ORNL04-0688
  • Grant Number: DE-AC05-00OR22725
  • DOI: 10.2172/944563 | External Link
  • Office of Scientific & Technical Information Report Number: 944563
  • Archival Resource Key: ark:/67531/metadc897774

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Office of Scientific & Technical Information Technical Reports

Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

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Creation Date

  • September 12, 2005

Added to The UNT Digital Library

  • Sept. 27, 2016, 1:39 a.m.

Description Last Updated

  • Oct. 20, 2016, 2:16 p.m.

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Wasson, J.S. & Lu, P.-Y. Use of Microarray Test Data for Toxicogenomic Prediction-Multi-Intelligent Systems for Toxicogenomic Applications (MISTA), report, September 12, 2005; Oak Ridge, Tennessee. (digital.library.unt.edu/ark:/67531/metadc897774/: accessed January 17, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.