Molecular Comb Development

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Description

This CRADA was developed to enable ORNL to assist Protein Discovery, Inc. to develop a novel biomolecular separation system based on an ORNL patent application 'Photoelectrochemical Molecular Comb' by Thundat, Ferrell, and Brown. The Molecular Comb concept is based on creating light-induced charge carriers at a semiconductor-liquid interface, which is kept at a potential control such that a depletion layer is formed in the semiconductor. Focusing light from a low-power illumination source creates electron-hole pairs, which get separated in the depletion layer. The light-induced charge carriers reaching the surface attract oppositely charged biomolecules present in the solution. The solution is ... continued below

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559 Kb

Creation Information

Ferrell, T.L.; Thundat, G.T. & Witkowski, C.E., III (Protein Discovery, Inc.) July 17, 2007.

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Description

This CRADA was developed to enable ORNL to assist Protein Discovery, Inc. to develop a novel biomolecular separation system based on an ORNL patent application 'Photoelectrochemical Molecular Comb' by Thundat, Ferrell, and Brown. The Molecular Comb concept is based on creating light-induced charge carriers at a semiconductor-liquid interface, which is kept at a potential control such that a depletion layer is formed in the semiconductor. Focusing light from a low-power illumination source creates electron-hole pairs, which get separated in the depletion layer. The light-induced charge carriers reaching the surface attract oppositely charged biomolecules present in the solution. The solution is a buffer solution with very small concentrations of biomolecules. As the focused light is moved across the surface of the semiconductor-liquid interface, the accumulated biomolecules follow the light beam. A thin layer of gel or other similar material on the surface of the semiconductor can act as a sieving medium for separating the biomolecules according to their sizes.

Physical Description

559 Kb

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  • Report No.: ORNL03-0671
  • Grant Number: DE-AC05-00OR22725
  • DOI: 10.2172/940307 | External Link
  • Office of Scientific & Technical Information Report Number: 940307
  • Archival Resource Key: ark:/67531/metadc897519

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Creation Date

  • July 17, 2007

Added to The UNT Digital Library

  • Sept. 27, 2016, 1:39 a.m.

Description Last Updated

  • Nov. 4, 2016, 7:19 p.m.

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Citations, Rights, Re-Use

Ferrell, T.L.; Thundat, G.T. & Witkowski, C.E., III (Protein Discovery, Inc.). Molecular Comb Development, report, July 17, 2007; Oak Ridge, Tennessee. (digital.library.unt.edu/ark:/67531/metadc897519/: accessed August 16, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.