High-Relaxivity MRI Contrast Agents: Where Coordination Chemistry Meets Medical Imaging

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The desire to improve and expand the scope of clinical magnetic resonance imaging (MRI) has prompted the search for contrast agents of higher efficiency. The development of better agents requires consideration of the fundamental coordination chemistry of the gadolinium(III) ion and the parameters that affect its efficacy as a proton relaxation agent. In optimizing each parameter, other practical issues such as solubility and in vivo toxicity must also be addressed, making the attainment of safe, high-relaxivity agents a challenging goal. Here we present recent advances in the field, with an emphasis on the hydroxypyridinone family of Gd{sup III} chelates.

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Werner, Eric J.; Datta, Ankona; Jocher, Christoph J. & Raymond, Kenneth N. January 15, 2008.

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Description

The desire to improve and expand the scope of clinical magnetic resonance imaging (MRI) has prompted the search for contrast agents of higher efficiency. The development of better agents requires consideration of the fundamental coordination chemistry of the gadolinium(III) ion and the parameters that affect its efficacy as a proton relaxation agent. In optimizing each parameter, other practical issues such as solubility and in vivo toxicity must also be addressed, making the attainment of safe, high-relaxivity agents a challenging goal. Here we present recent advances in the field, with an emphasis on the hydroxypyridinone family of Gd{sup III} chelates.

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  • Journal Name: Angewandte Chemie International Edition; Journal Volume: 47; Related Information: Journal Publication Date: 2008

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  • Report No.: LBNL-1192E
  • Grant Number: DE-AC02-05CH11231
  • Grant Number: HL69832
  • DOI: 10.1002/anie.200800212 | External Link
  • Office of Scientific & Technical Information Report Number: 942144
  • Archival Resource Key: ark:/67531/metadc897512

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  • January 15, 2008

Added to The UNT Digital Library

  • Sept. 27, 2016, 1:39 a.m.

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  • Sept. 30, 2016, 6:35 p.m.

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Werner, Eric J.; Datta, Ankona; Jocher, Christoph J. & Raymond, Kenneth N. High-Relaxivity MRI Contrast Agents: Where Coordination Chemistry Meets Medical Imaging, article, January 15, 2008; Berkeley, California. (digital.library.unt.edu/ark:/67531/metadc897512/: accessed September 25, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.