Pestoides F, and Atypical Yersinia pestis Strain from the Former Soviet Union

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Description

Unlike the classical Yersinia pestis strains, members of an atypical group of Y. pestis from Central Asia, denominated Y. pestis subspecies caucasica (also known as one of several pestoides types), are distinguished by a number of characteristics including their ability to ferment rhamnose and melibiose, their lacking the small plasmid encoding the plasminogen activator (pla) and pesticin, and their exceptionally large variants of the virulence plasmid pMT (encoding murine toxin and capsular antigen). We have obtained the entire genome sequence of Y. pestis Pestoides F, an isolate from the former Soviet Union that has enabled us to carryout a comprehensive ... continued below

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8 p. (0.2 MB)

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Garcia, E.; Worsham, P.; Bearden, S.; Malfatti, S.; Lang, D.; Larimer, F. et al. January 5, 2007.

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Description

Unlike the classical Yersinia pestis strains, members of an atypical group of Y. pestis from Central Asia, denominated Y. pestis subspecies caucasica (also known as one of several pestoides types), are distinguished by a number of characteristics including their ability to ferment rhamnose and melibiose, their lacking the small plasmid encoding the plasminogen activator (pla) and pesticin, and their exceptionally large variants of the virulence plasmid pMT (encoding murine toxin and capsular antigen). We have obtained the entire genome sequence of Y. pestis Pestoides F, an isolate from the former Soviet Union that has enabled us to carryout a comprehensive genome-wide comparison of this organism's genomic content against the six published sequences of Y. pestis and their Y. pseudotuberculosis ancestor. Based on classical glycerol fermentation (+ve) and nitrate reduction (+ve) Y. pestis Pestoides F is an isolate that belongs to the biovar antiqua. This strain is unusual in other characteristics such as the fact that it carries a non-consensus V antigen (lcrV) sequence, and that unlike other Pla{sup -} strains, Pestoides F retains virulence by the parenteral and aerosol routes. The chromosome of Pestoides F is 4,517,345 bp in size comprising some 3,936 predicted coding sequences, while its pCD and pMT plasmids are 71,507 bp and 137,010 bp in size respectively. Comparison of chromosome-associated genes in Pestoides F with those in the other sequenced Y. pestis strains, reveals a series of differences ranging from strain-specific rearrangements, insertions, deletions, single nucleotide polymorphisms, and a unique distribution of insertion sequences. There is a single {approx}7 kb unique region in the chromosome not found in any of the completed Y. pestis strains sequenced to date, but which is present in the Y. pseudotuberculosis ancestor. Taken together, these findings are consistent with Pestoides F being derived from the most ancient lineage of Y. pestis yet sequenced.

Physical Description

8 p. (0.2 MB)

Notes

PDF-file: 8 pages; size: 0.2 Mbytes

Source

  • Proceedings of the 9th International Symposium on Yersinia, Pestoides F, and Atypical Yersinia pestis Strain from the Former Soviet Union, Adv Exp Med Biol, Chicago, IL 2007, pp. 603:17-22

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  • Report No.: UCRL-BOOK-227152
  • Grant Number: W-7405-ENG-48
  • Office of Scientific & Technical Information Report Number: 936979
  • Archival Resource Key: ark:/67531/metadc897021

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Office of Scientific & Technical Information Technical Reports

Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

Office of Scientific and Technical Information (OSTI) is the Department of Energy (DOE) office that collects, preserves, and disseminates DOE-sponsored research and development (R&D) results that are the outcomes of R&D projects or other funded activities at DOE labs and facilities nationwide and grantees at universities and other institutions.

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Creation Date

  • January 5, 2007

Added to The UNT Digital Library

  • Sept. 27, 2016, 1:39 a.m.

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  • April 17, 2017, 2:06 p.m.

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Garcia, E.; Worsham, P.; Bearden, S.; Malfatti, S.; Lang, D.; Larimer, F. et al. Pestoides F, and Atypical Yersinia pestis Strain from the Former Soviet Union, book, January 5, 2007; Livermore, California. (digital.library.unt.edu/ark:/67531/metadc897021/: accessed December 13, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.