Analysis of Non-Enzymatically Glycated Peptides: Neutral-Loss Triggered MS3 Versus Multi-Stage Activation Tandem Mass Spectrometry Page: 3 of 5
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IVC-17/ICSS-13 and ICN+T2007
Journal of Physics: Conference Series 100 (2008) 012036
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doi:10.1088/1742-6596/100/1/012036r4i V
ftFigure 1. Cross-sectional SEM micrographs of AlON films: (a) sample I and (b) sample II.
Elemental depth profiling was done with Time-of-Flight elastic recoil detection analysis using a 40
MeV 12.19+ ion beam. The incoming ion beam and outgoing recoils impinged/exited at 67.50 to the
sample surface normal, respectively, giving a recoil angle of 450 A detailed description of the
experimental set-up has been given elsewhere [7]. The time-of-flight and the energy signals for each
recoil were recorded and the recoil energy of each element was converted to elemental depth profiles
using the CONTES code [8]. In addition the samples were analysed with X-ray photoelectron
spectroscopy (XPS) in combination with sputter depth profiling using a PHI Quantum 2000 instrument
with monochromatised Al K alpha radiation. The O Is, N Is, Al 2p, Si 2p and C Is peaks were used to
monitor the relative atomic contents using the peak area to extract the relative concentration with
sensitivity factors supplied. The pass energy used for the elemental surveys is 23.5 eV and the
resolution of the instrument +/- 0.1 eV. The X-ray spot size in the XPS was 100 m diameter. The
sputtering was performed with a 4.0 keV ArC beam, raster size 1x1 mm2. Film thickness was measured
using a LEO 1550 FEG scanning electron microscope (SEM).
3. Results and Discussion
The deposited films studied here, indicated as sample I and II, have a columnar structure, as seen in
figure 1, with thicknesses of 450 nm and 240 nm, respectively. However neither film shows any strong
crystallographic orientation, as seen by X-ray diffraction measurements in figure 2 (a). This could be
indicative of the films having an amorphous structure or could in part be due to the influence of the32 36 40 4448 52 56 60 64 68 72 76 80 84 88
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Binding Energy (eV)Figure 2. (a) Diffractograms of sample I and II, the strong peak is from the Si substrate. (b) XPS
depth profiling spectra of Al 2p peak region for sample I.1E7
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Zhang, Qibin; Petyuk, Vladislav A.; Schepmoes, Athena A.; Orton, Daniel J.; Monroe, Matthew E.; Yang, Feng et al. Analysis of Non-Enzymatically Glycated Peptides: Neutral-Loss Triggered MS3 Versus Multi-Stage Activation Tandem Mass Spectrometry, article, October 15, 2008; Richland, Washington. (https://digital.library.unt.edu/ark:/67531/metadc896489/m1/3/: accessed April 23, 2024), University of North Texas Libraries, UNT Digital Library, https://digital.library.unt.edu; crediting UNT Libraries Government Documents Department.