Three-dimensional architecture of hair-cell linkages as revealedby electron-microscopic tomography

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The senses of hearing and balance rest upon mechanoelectrical transduction by the hair bundles of hair cells in the inner ear. Located at the apical cellular surface, each hair bundle comprises several tens of stereocilia and a single kinocilium that are interconnected by extracellular proteinaceous links. Using electron-microscopic tomography of bullfrog saccular sensory epithelia, we examined the three-dimensional structures of ankle or basal links, kinociliary links, and tip links. We observed clear differences in the dimensions and appearances of the three links. We found two distinct populations of tip links suggestive of the involvement of two proteins or splice variants. ... continued below

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Auer, Manfred; Koster, Bram; Ziese, Ulrike; Bajaj, Chandrajit; Volkmann, Niels; Wang, Da Neng et al. July 28, 2006.

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The senses of hearing and balance rest upon mechanoelectrical transduction by the hair bundles of hair cells in the inner ear. Located at the apical cellular surface, each hair bundle comprises several tens of stereocilia and a single kinocilium that are interconnected by extracellular proteinaceous links. Using electron-microscopic tomography of bullfrog saccular sensory epithelia, we examined the three-dimensional structures of ankle or basal links, kinociliary links, and tip links. We observed clear differences in the dimensions and appearances of the three links. We found two distinct populations of tip links suggestive of the involvement of two proteins or splice variants. We noted auxiliary links connecting the upper portions of tip links to the taller stereocilia. Tip links and auxiliary links show a tendency to adopt a globular conformation when disconnected from the membrane surface.

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  • Journal Name: Journal of Neuroscience; Journal Volume: 9; Journal Issue: 2; Related Information: Journal Publication Date: 06/2008

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  • Report No.: LBNL--61181
  • Grant Number: DE-AC02-05CH11231
  • Office of Scientific & Technical Information Report Number: 929758
  • Archival Resource Key: ark:/67531/metadc896240

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  • July 28, 2006

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  • Sept. 27, 2016, 1:39 a.m.

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  • Sept. 21, 2017, 3:56 p.m.

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Auer, Manfred; Koster, Bram; Ziese, Ulrike; Bajaj, Chandrajit; Volkmann, Niels; Wang, Da Neng et al. Three-dimensional architecture of hair-cell linkages as revealedby electron-microscopic tomography, article, July 28, 2006; Berkeley, California. (digital.library.unt.edu/ark:/67531/metadc896240/: accessed November 19, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.