Screening Program Reduced Melanoma Mortality at the Lawrence Livermore National Laboratory, 1984-1996

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Worldwide incidence of cutaneous malignant melanoma has increased substantially, and no screening program has yet demonstrated reduction in mortality. We evaluated the education, self examination and targeted screening campaign at the Lawrence Livermore National Laboratory (LLNL) from its beginning in July 1984 through 1996. The thickness and crude incidence of melanoma from the years before the campaign were compared to those obtained during the 13 years of screening. Melanoma mortality during the 13-year period was based on a National Death Index search. Expected yearly deaths from melanoma among LLNL employees were calculated by using California mortality data matched by age, ... continued below

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Schneider, MD, J S; II, PhD, D & MD, PhD, M October 12, 2006.

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Worldwide incidence of cutaneous malignant melanoma has increased substantially, and no screening program has yet demonstrated reduction in mortality. We evaluated the education, self examination and targeted screening campaign at the Lawrence Livermore National Laboratory (LLNL) from its beginning in July 1984 through 1996. The thickness and crude incidence of melanoma from the years before the campaign were compared to those obtained during the 13 years of screening. Melanoma mortality during the 13-year period was based on a National Death Index search. Expected yearly deaths from melanoma among LLNL employees were calculated by using California mortality data matched by age, sex, and race/ethnicity and adjusted to exclude deaths from melanoma diagnosed before the program began or before employment at LLNL. After the program began, crude incidence of melanoma thicker than 0.75 mm decreased from 18 to 4 cases per 100,000 person-years (p = 0.02), while melanoma less than 0.75mm remained stable and in situ melanoma increased substantially. No eligible melanoma deaths occurred among LLNL employees during the screening period compared with a calculated 3.39 expected deaths (p = 0.034). Education, self examination and selective screening for melanoma at LLNL significantly decreased incidence of melanoma thicker than 0.75 mm and reduced the melanoma-related mortality rate to zero. This significant decrease in mortality rate persisted for at least 3 yr after employees retired or otherwise left the laboratory.

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PDF-file: 23 pages; size: 0.2 Mbytes

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  • Journal Name: Journal of the American Academy of Dermatology, vol. 58, no. 5, February 20, 2008, pp. 741-9; Journal Volume: 58; Journal Issue: 5

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  • Report No.: UCRL-JRNL-229411
  • Grant Number: W-7405-ENG-48
  • Office of Scientific & Technical Information Report Number: 940162
  • Archival Resource Key: ark:/67531/metadc896038

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Office of Scientific & Technical Information Technical Reports

Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

Office of Scientific and Technical Information (OSTI) is the Department of Energy (DOE) office that collects, preserves, and disseminates DOE-sponsored research and development (R&D) results that are the outcomes of R&D projects or other funded activities at DOE labs and facilities nationwide and grantees at universities and other institutions.

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  • October 12, 2006

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  • Sept. 27, 2016, 1:39 a.m.

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  • Dec. 8, 2016, 10:04 p.m.

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Schneider, MD, J S; II, PhD, D & MD, PhD, M. Screening Program Reduced Melanoma Mortality at the Lawrence Livermore National Laboratory, 1984-1996, article, October 12, 2006; Livermore, California. (digital.library.unt.edu/ark:/67531/metadc896038/: accessed December 11, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.