Mechanisms of disease: epithelial-mesenchymal transition and back again: does cellular plasticity fuel neoplastic progression?

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Epithelial-mesenchymal transition (EMT) is a conversion that facilitates organ morphogenesis and tissue remodeling in physiological processes such as embryonic development and wound healing. A similar phenotypic conversion is also detected in fibrotic diseases and neoplasia, which is associated with disease progression. EMT in cancer epithelial cells often seems to be an incomplete and bi-directional process. In this Review, we discuss the phenomenon of EMT as it pertains to tumor development, focusing on exceptions to the commonly held rule that EMT promotes invasion and metastasis. We also highlight the role of the RAS-controlled signaling mediators, ERK1, ERK2 and PI3-kinase, as microenvironmental ... continued below

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Bissell, Mina J; Turley, Eva A.; Veiseh, Mandana; Radisky, Derek C. & Bissell, Mina J. February 13, 2008.

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Epithelial-mesenchymal transition (EMT) is a conversion that facilitates organ morphogenesis and tissue remodeling in physiological processes such as embryonic development and wound healing. A similar phenotypic conversion is also detected in fibrotic diseases and neoplasia, which is associated with disease progression. EMT in cancer epithelial cells often seems to be an incomplete and bi-directional process. In this Review, we discuss the phenomenon of EMT as it pertains to tumor development, focusing on exceptions to the commonly held rule that EMT promotes invasion and metastasis. We also highlight the role of the RAS-controlled signaling mediators, ERK1, ERK2 and PI3-kinase, as microenvironmental responsive regulators of EMT.

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  • Journal Name: National Clinical Practice Oncology; Related Information: Journal Publication Date: 03/18/2008

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  • Report No.: LBNL-174E
  • Grant Number: DE-AC02-05CH11231
  • Office of Scientific & Technical Information Report Number: 927136
  • Archival Resource Key: ark:/67531/metadc892959

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  • February 13, 2008

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  • Sept. 27, 2016, 1:39 a.m.

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  • Oct. 3, 2016, 1:54 p.m.

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Bissell, Mina J; Turley, Eva A.; Veiseh, Mandana; Radisky, Derek C. & Bissell, Mina J. Mechanisms of disease: epithelial-mesenchymal transition and back again: does cellular plasticity fuel neoplastic progression?, article, February 13, 2008; Berkeley, California. (digital.library.unt.edu/ark:/67531/metadc892959/: accessed August 17, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.