Accelerator mass spectrometry for quantitative in vivo tracing

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Description

Accelerator mass spectrometry (AMS) counts individual rare, usually radio-, isotopes such as radiocarbon at high efficiency and specificity in milligram-sized samples. AMS traces very low chemical doses ({micro}g) and radiative doses (100 Bq) of isotope labeled compounds in animal models and directly in humans for pharmaceutical, nutritional, or toxicological research. Absorption, metabolism, distribution, binding, and elimination are all quantifiable with high precision after appropriate sample definition.

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PDF-file: 23 pages; size: 3 Mbytes

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Vogel, J S April 19, 2005.

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Description

Accelerator mass spectrometry (AMS) counts individual rare, usually radio-, isotopes such as radiocarbon at high efficiency and specificity in milligram-sized samples. AMS traces very low chemical doses ({micro}g) and radiative doses (100 Bq) of isotope labeled compounds in animal models and directly in humans for pharmaceutical, nutritional, or toxicological research. Absorption, metabolism, distribution, binding, and elimination are all quantifiable with high precision after appropriate sample definition.

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PDF-file: 23 pages; size: 3 Mbytes

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  • Journal Name: Biotechniques; Journal Volume: 38

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  • Report No.: UCRL-JRNL-211545
  • Grant Number: W-7405-ENG-48
  • Office of Scientific & Technical Information Report Number: 883815
  • Archival Resource Key: ark:/67531/metadc892802

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Office of Scientific & Technical Information Technical Reports

Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

Office of Scientific and Technical Information (OSTI) is the Department of Energy (DOE) office that collects, preserves, and disseminates DOE-sponsored research and development (R&D) results that are the outcomes of R&D projects or other funded activities at DOE labs and facilities nationwide and grantees at universities and other institutions.

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  • April 19, 2005

Added to The UNT Digital Library

  • Sept. 23, 2016, 2:42 p.m.

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  • Dec. 8, 2016, 2:10 p.m.

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Vogel, J S. Accelerator mass spectrometry for quantitative in vivo tracing, article, April 19, 2005; Livermore, California. (digital.library.unt.edu/ark:/67531/metadc892802/: accessed December 16, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.