Unraveling the Fanconi anaemia-DNA repair connection through DNA helicase and translocase activities

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How the Fanconi anaemia (FA) chromosome stability pathway functions to cope with interstrand crosslinks and other DNA lesions has been elusive, even after FANCD1 proved to be BRCA2, a partner of Rad51 in homologous recombination. The identification and characterization of two new Fanconi proteins having helicase motifs, FANCM and FANCJ/BRIP1/BACH1, implicates the FANC nuclear core complex as a participant in recognizing or processing damaged DNA, and the BRIP1 helicase as acting independently of this complex.

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7 p. (0.2 MB)

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Thompson, L H August 16, 2005.

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How the Fanconi anaemia (FA) chromosome stability pathway functions to cope with interstrand crosslinks and other DNA lesions has been elusive, even after FANCD1 proved to be BRCA2, a partner of Rad51 in homologous recombination. The identification and characterization of two new Fanconi proteins having helicase motifs, FANCM and FANCJ/BRIP1/BACH1, implicates the FANC nuclear core complex as a participant in recognizing or processing damaged DNA, and the BRIP1 helicase as acting independently of this complex.

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7 p. (0.2 MB)

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PDF-file: 7 pages; size: 0.2 Mbytes

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  • Journal Name: Nature Genetics; Journal Volume: 37; Journal Issue: 9

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  • Report No.: UCRL-JRNL-214659
  • Grant Number: W-7405-ENG-48
  • Office of Scientific & Technical Information Report Number: 883737
  • Archival Resource Key: ark:/67531/metadc892412

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Office of Scientific & Technical Information Technical Reports

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  • August 16, 2005

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  • Sept. 23, 2016, 2:42 p.m.

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  • April 17, 2017, 12:54 p.m.

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Thompson, L H. Unraveling the Fanconi anaemia-DNA repair connection through DNA helicase and translocase activities, article, August 16, 2005; Livermore, California. (digital.library.unt.edu/ark:/67531/metadc892412/: accessed July 18, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.