Magnetic gradiometer based on a high-transition temperature superconducting quantum interference device for improved sensitivity of abiosensor

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We describe a gradiometer based on a high-transition temperature Superconducting Quantum Interference Device (SQUID) for improving the sensitivity of a SQUID-based biosensor. The first-derivative gradiometer, fabricated from a single layer of YBa{sub 2}Cu{sub 3}O{sub 7-x}, has a baseline of 480 {micro}m and a balance against uniform fields of 1 part in 150. Used in our SQUID ''microscope,'' it reduces parasitic magnetic fields generated by the measurement process to the level of the SQUID noise. The gradiometer-based microscope is two orders of magnitude more sensitive to super paramagnetic nanoparticles bound to biological targets than our earlier magnetometer-based microscope.

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Lee, Seung Kyun; Myers, W. R.; Grossman, H. L.; Cho, H.-M.; Chemla,Y. R. & Clarke, John July 8, 2002.

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Description

We describe a gradiometer based on a high-transition temperature Superconducting Quantum Interference Device (SQUID) for improving the sensitivity of a SQUID-based biosensor. The first-derivative gradiometer, fabricated from a single layer of YBa{sub 2}Cu{sub 3}O{sub 7-x}, has a baseline of 480 {micro}m and a balance against uniform fields of 1 part in 150. Used in our SQUID ''microscope,'' it reduces parasitic magnetic fields generated by the measurement process to the level of the SQUID noise. The gradiometer-based microscope is two orders of magnitude more sensitive to super paramagnetic nanoparticles bound to biological targets than our earlier magnetometer-based microscope.

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  • Journal Name: Applied Physics Letters; Journal Volume: 81; Journal Issue: 16; Related Information: Journal Publication Date: 10/14/2002

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  • Report No.: LBNL--51454
  • Grant Number: DE-AC02-05CH11231
  • DOI: 10.1063/1.1515122 | External Link
  • Office of Scientific & Technical Information Report Number: 917520
  • Archival Resource Key: ark:/67531/metadc890112

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Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

Office of Scientific and Technical Information (OSTI) is the Department of Energy (DOE) office that collects, preserves, and disseminates DOE-sponsored research and development (R&D) results that are the outcomes of R&D projects or other funded activities at DOE labs and facilities nationwide and grantees at universities and other institutions.

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  • July 8, 2002

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  • Sept. 22, 2016, 2:13 a.m.

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  • Dec. 1, 2017, 10:05 p.m.

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Lee, Seung Kyun; Myers, W. R.; Grossman, H. L.; Cho, H.-M.; Chemla,Y. R. & Clarke, John. Magnetic gradiometer based on a high-transition temperature superconducting quantum interference device for improved sensitivity of abiosensor, article, July 8, 2002; Berkeley, California. (digital.library.unt.edu/ark:/67531/metadc890112/: accessed January 17, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.