Bioagent detection using miniaturized NMR and nanoparticle amplification : final LDRD report. Metadata

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  • Main Title Bioagent detection using miniaturized NMR and nanoparticle amplification : final LDRD report.


  • Author: Clewett, C. F. M.
    Creator Type: Personal
  • Author: Adams, David Price
    Creator Type: Personal
  • Author: Fan, Hongyou
    Creator Type: Personal
  • Author: Williams, John D.
    Creator Type: Personal
  • Author: Sillerud, Laurel O.
    Creator Type: Personal
  • Author: Alam, Todd Michael
    Creator Type: Personal
  • Author: Aldophi, Natalie L. (New Mexico Resonance, Albuquerque, NM)
    Creator Type: Personal
  • Author: McDowell, Andrew F. (New Mexico Resonance, Albuquerque, NM)
    Creator Type: Personal


  • Sponsor: United States. Department of Energy.
    Contributor Type: Organization


  • Name: Sandia National Laboratories
    Place of Publication: United States


  • Creation: 2006-11-01


  • English


  • Content Description: This LDRD program was directed towards the development of a portable micro-nuclear magnetic resonance ({micro}-NMR) spectrometer for the detection of bioagents via induced amplification of solvent relaxation based on superparamagnetic nanoparticles. The first component of this research was the fabrication and testing of two different micro-coil ({micro}-coil) platforms: namely a planar spiral NMR {micro}-coil and a cylindrical solenoid NMR {micro}-coil. These fabrication techniques are described along with the testing of the NMR performance for the individual coils. The NMR relaxivity for a series of water soluble FeMn oxide nanoparticles was also determined to explore the influence of the nanoparticle size on the observed NMR relaxation properties. In addition, The use of commercially produced superparamagnetic iron oxide nanoparticles (SPIONs) for amplification via NMR based relaxation mechanisms was also demonstrated, with the lower detection limit in number of SPIONs per nanoliter (nL) being determined.
  • Physical Description: 87 p.


  • Keyword: Spectrometers
  • Keyword: Biological Warfare Agents
  • STI Subject Categories: 98 Nuclear Disarmament, Safeguards, And Physical Protection
  • Keyword: Sensitivity
  • Keyword: Performance Testing
  • Keyword: Miniaturization
  • Keyword: Detection
  • Keyword: Fabrication
  • STI Subject Categories: 45 Military Technology, Weaponry, And National Defense
  • Keyword: Nuclear Magnetic Resonance


  • Name: Office of Scientific & Technical Information Technical Reports
    Code: OSTI


  • Name: UNT Libraries Government Documents Department
    Code: UNTGD

Resource Type

  • Report


  • Text


  • Report No.: SAND2006-6931
  • Grant Number: AC04-94AL85000
  • DOI: 10.2172/896855
  • Office of Scientific & Technical Information Report Number: 896855
  • Archival Resource Key: ark:/67531/metadc890032