Field-Portable Immunoassay Instruments and Reagents to Measure Chelators and Mobile Forms of Uranium

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Description

The goals for the 3-year project period are (1) to test and validate the present uranium sensor and develop protocols for its use at the NABIR Field Research Center; (2) to develop new reagents that will provide superior performance for the present hand-held immunosensor; and (3) to develop new antibodies that will permit this sensor to also measure other environmental contaminants (chromium, mercury, and/or DTPA). Sensor design modifications are underway via international collaborations. New reagents that will provide superior performance for the present hand-held immunosensor are being prepared and tested. New methods have been developed, to produce recombinant forms of ... continued below

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Blake, Diane A. June 1, 2003.

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Description

The goals for the 3-year project period are (1) to test and validate the present uranium sensor and develop protocols for its use at the NABIR Field Research Center; (2) to develop new reagents that will provide superior performance for the present hand-held immunosensor; and (3) to develop new antibodies that will permit this sensor to also measure other environmental contaminants (chromium, mercury, and/or DTPA). Sensor design modifications are underway via international collaborations. New reagents that will provide superior performance for the present hand-held immunosensor are being prepared and tested. New methods have been developed, to produce recombinant forms of metal-specific monoclonal antibodies for use with the sensor. Site-directed mutagenesis experiments are underway to determine the mechanisms of binding. Immunization experiments with sheep and rabbits to develop new recombinant forms of antibodies to metal-chelate complexes (chromium, mercury, and/or DTPA) have been initiated.

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  • Report No.: NABIR-1011983-2003
  • Grant Number: None
  • DOI: 10.2172/893777 | External Link
  • Office of Scientific & Technical Information Report Number: 893777
  • Archival Resource Key: ark:/67531/metadc888929

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  • June 1, 2003

Added to The UNT Digital Library

  • Sept. 22, 2016, 2:13 a.m.

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  • Nov. 4, 2016, 6:23 p.m.

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Blake, Diane A. Field-Portable Immunoassay Instruments and Reagents to Measure Chelators and Mobile Forms of Uranium, report, June 1, 2003; United States. (digital.library.unt.edu/ark:/67531/metadc888929/: accessed August 16, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.