Sensitivity Enhancement by Exchange Mediated MagnetizationTransfer of the Xenon Biosensor Signal

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Hyperpolarized xenon associated with ligand derivitized cryptophane-A cages has been developed as a NMR based biosensor. To optimize the detection sensitivity we describe use of xenon exchange between the caged and bulk dissolved xenon as an effective signal amplifier. This approach, somewhat analogous to 'remote detection' described recently, uses the chemical exchange to repeatedly transfer spectroscopic information from caged to bulk xenon, effectively integrating the caged signal. After an optimized integration period, the signal is read out by observation of the bulk magnetization. The spectrum of the caged xenon is reconstructed through use of a variable evolution period before transfer ... continued below

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Garcia, Sandra; Chavez, Lana; Lowery, Thomas J.; Han, Song-I.; Wemmer, David E. & Pines, Alexander August 31, 2006.

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Hyperpolarized xenon associated with ligand derivitized cryptophane-A cages has been developed as a NMR based biosensor. To optimize the detection sensitivity we describe use of xenon exchange between the caged and bulk dissolved xenon as an effective signal amplifier. This approach, somewhat analogous to 'remote detection' described recently, uses the chemical exchange to repeatedly transfer spectroscopic information from caged to bulk xenon, effectively integrating the caged signal. After an optimized integration period, the signal is read out by observation of the bulk magnetization. The spectrum of the caged xenon is reconstructed through use of a variable evolution period before transfer and Fourier analysis of the bulk signal as a function of the evolution time.

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  • Journal Name: Journal of Magnetic Resonance; Journal Volume: 184; Journal Issue: 1; Related Information: Journal Publication Date: 01/2007

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  • Report No.: LBNL--61550
  • Grant Number: DE-AC02-05CH11231
  • Office of Scientific & Technical Information Report Number: 918926
  • Archival Resource Key: ark:/67531/metadc888832

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  • August 31, 2006

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  • Sept. 22, 2016, 2:13 a.m.

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  • Oct. 31, 2016, 3:58 p.m.

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Garcia, Sandra; Chavez, Lana; Lowery, Thomas J.; Han, Song-I.; Wemmer, David E. & Pines, Alexander. Sensitivity Enhancement by Exchange Mediated MagnetizationTransfer of the Xenon Biosensor Signal, article, August 31, 2006; Berkeley, California. (digital.library.unt.edu/ark:/67531/metadc888832/: accessed December 13, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.