Final report on Grant DE-FG03-01ER63234

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Current data suggests that radiation-induced bystander effects (RIBE) are associated with release of active polypeptide factors into the extra-cellular medium. Proteolytic processing of membrane-anchored cytokines (shedding) is a generic cellular response to environmental stress; hence, it is likely that RIBE are part of a general mechanism by which cells alert their neighbors to potential harm by exchange of autocrine and paracrine factors. In radiation biology, we lack a general understanding of the relative importance of shed factors in the overall response of tissues to energy absorbed from a radiation field. This project helped fill that knowledge gap by investigating (1) ... continued below

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Miller, John H. November 16, 2006.

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Description

Current data suggests that radiation-induced bystander effects (RIBE) are associated with release of active polypeptide factors into the extra-cellular medium. Proteolytic processing of membrane-anchored cytokines (shedding) is a generic cellular response to environmental stress; hence, it is likely that RIBE are part of a general mechanism by which cells alert their neighbors to potential harm by exchange of autocrine and paracrine factors. In radiation biology, we lack a general understanding of the relative importance of shed factors in the overall response of tissues to energy absorbed from a radiation field. This project helped fill that knowledge gap by investigating (1) the production of soluble factors by cells traversed by ionizing particles, (2) transport of soluble factors through the extra-cellular medium, and (3) signaling processes initiate by capture of soluble factors on cell-surface receptors.

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34 kB

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  • Report No.: DOE/ER/63234-1
  • Grant Number: FG03-01ER63234
  • DOI: 10.2172/895066 | External Link
  • Office of Scientific & Technical Information Report Number: 895066
  • Archival Resource Key: ark:/67531/metadc888228

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Office of Scientific & Technical Information Technical Reports

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  • November 16, 2006

Added to The UNT Digital Library

  • Sept. 22, 2016, 2:13 a.m.

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  • Nov. 7, 2016, 2:07 p.m.

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Miller, John H. Final report on Grant DE-FG03-01ER63234, report, November 16, 2006; United States. (digital.library.unt.edu/ark:/67531/metadc888228/: accessed November 18, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.