Antibody elbow angles are influenced by their light chain class

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We have examined the elbow angles for 365 different Fab fragments, and observe that Fabs with lambda light chains have adopted a wider range of elbow angles than their kappa-chain counterparts, and that the lambda light chain Fabs are frequently found with very large (>195{sup o}) elbow angles. This apparent hyperflexibility of lambda-chain Fabs may be due to an insertion in their switch region, which is one residue longer than in kappa chains, with glycine occurring most frequently at the insertion position. A new, web-based computer program that was used to calculate the Fab elbow angles is also described.

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PDF-file: 27 pages; size: 1.5 Mbytes

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Stanfield, R; Zemla, A; Wilson, I & Rupp, B January 12, 2006.

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We have examined the elbow angles for 365 different Fab fragments, and observe that Fabs with lambda light chains have adopted a wider range of elbow angles than their kappa-chain counterparts, and that the lambda light chain Fabs are frequently found with very large (>195{sup o}) elbow angles. This apparent hyperflexibility of lambda-chain Fabs may be due to an insertion in their switch region, which is one residue longer than in kappa chains, with glycine occurring most frequently at the insertion position. A new, web-based computer program that was used to calculate the Fab elbow angles is also described.

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PDF-file: 27 pages; size: 1.5 Mbytes

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  • Journal Name: Journal of Molecular Biology, vol. 357, no. 5, April 14, 2006, pp. 1566-1574

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  • Report No.: UCRL-JRNL-218128
  • Grant Number: W-7405-ENG-48
  • Office of Scientific & Technical Information Report Number: 898021
  • Archival Resource Key: ark:/67531/metadc887261

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  • January 12, 2006

Added to The UNT Digital Library

  • Sept. 22, 2016, 2:13 a.m.

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  • Nov. 22, 2016, 7:10 p.m.

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Stanfield, R; Zemla, A; Wilson, I & Rupp, B. Antibody elbow angles are influenced by their light chain class, article, January 12, 2006; Livermore, California. (digital.library.unt.edu/ark:/67531/metadc887261/: accessed September 20, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.