Advantages of improved timing accuracy in PET cameras using LSOscintillator

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PET scanners based on LSO have the potential forsignificantly better coincidence timing resolution than the 6 ns fwhmtypically achieved with BGO. This study analyzes the performanceenhancements made possible by improved timing as a function of thecoincidence time resolution. If 500 ps fwhm coincidence timing resolutioncan be achieved in a complete PET camera, the following four benefits canbe realized for whole-body FDG imaging: 1) The random event rate can bereduced by using a narrower coincidence timing window, increasing thepeak NECR by~;50 percent. 2) Using time-of-flight in the reconstructionalgorithm will reduce the noise variance by a factor of 5. 3) Emissionand transmission ... continued below

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Moses, William W. December 2, 2002.

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PET scanners based on LSO have the potential forsignificantly better coincidence timing resolution than the 6 ns fwhmtypically achieved with BGO. This study analyzes the performanceenhancements made possible by improved timing as a function of thecoincidence time resolution. If 500 ps fwhm coincidence timing resolutioncan be achieved in a complete PET camera, the following four benefits canbe realized for whole-body FDG imaging: 1) The random event rate can bereduced by using a narrower coincidence timing window, increasing thepeak NECR by~;50 percent. 2) Using time-of-flight in the reconstructionalgorithm will reduce the noise variance by a factor of 5. 3) Emissionand transmission data can be acquired simultaneously, reducing the totalscan time. 4) Axial blurring can be reduced by using time-of-flight todetermine the correct axial plane that each event originated from. Whiletime-of-flight was extensively studied in the 1980's, practical factorslimited its effectiveness at that time and little attention has been paidto timing in PET since then. As these potential improvements aresubstantial and the advent of LSO PET cameras gives us the means toobtain them without other sacrifices, efforts to improve PET timingshould resume after their long dormancy.

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  • Journal Name: IEEE Transactions on Nuclear Science; Journal Volume: 3; Related Information: Journal Publication Date: 11/2002

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  • Report No.: LBNL--51788
  • Grant Number: DE-AC02-05CH11231
  • Office of Scientific & Technical Information Report Number: 894973
  • Archival Resource Key: ark:/67531/metadc887156

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  • December 2, 2002

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  • Sept. 22, 2016, 2:13 a.m.

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  • Sept. 29, 2016, 1:37 p.m.

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Moses, William W. Advantages of improved timing accuracy in PET cameras using LSOscintillator, article, December 2, 2002; Berkeley, California. (digital.library.unt.edu/ark:/67531/metadc887156/: accessed August 23, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.