Accelerated Gene Evolution and Subfunctionalization in the Pseudotetraploid Frog Xenopus Laevis Page: 2 of 50
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Ancient whole genome duplications have been implicated in the vertebrate and
teleost radiations, and in the emergence of diverse angiosperm lineages, but the
evolutionary response to such a perturbation is still poorly understood. The
African clawed frog Xenopus laevis experienced a relatively recent
tetraploidization ~ 40 million years ago. Analysis of the considerable amount of
EST sequence available for this species together with the genome sequence of
the related diploid Xenopus tropicalis provides a unique opportunity to study the
genomic response to whole genome duplication.
We identified 2 218 gene triplets in which a single gene in X. tropicalis
corresponds to precisely two co-orthologous genes in X. laevis - the largest such
collection published from any duplication event in animals. Analysis of these
triplets reveals accelerated evolution or relaxation of constraint in the peptides of
the X. laevis pairs compared with the orthologous sequences in X. tropicalis and
other vertebrates. In contrast, single-copy X. laevis genes do not show this
acceleration. Duplicated genes can differ substantially in expression levels and
patterns. We find no significant difference in gene content in the duplicated set,
versus the single-copy set based on molecular and biological function ontologies.
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Hellsten, Uffe; Khokha, Mustafa K.; Grammar, Timothy C.; Harland,Richard M.; Richardson, Paul & Rokhsar, Daniel S. Accelerated Gene Evolution and Subfunctionalization in the Pseudotetraploid Frog Xenopus Laevis, article, March 1, 2007; Berkeley, California. (https://digital.library.unt.edu/ark:/67531/metadc886588/m1/2/: accessed April 24, 2019), University of North Texas Libraries, Digital Library, https://digital.library.unt.edu; crediting UNT Libraries Government Documents Department.