Primate-specific evolution of an LDLR enhancer Metadata

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Title

  • Main Title Primate-specific evolution of an LDLR enhancer

Creator

  • Author: Wang, Qian-Fei
    Creator Type: Personal
  • Author: Prabhakar, Shyam
    Creator Type: Personal
  • Author: Wang, Qianben
    Creator Type: Personal
  • Author: Moses, Alan M.
    Creator Type: Personal
  • Author: Chanan, Sumita
    Creator Type: Personal
  • Author: Brown, Myles
    Creator Type: Personal
  • Author: Eisen, Michael B.
    Creator Type: Personal
  • Author: Cheng, Jan-Fang
    Creator Type: Personal
  • Author: Rubin,Edward M.
    Creator Type: Personal
  • Author: Boffelli, Dario
    Creator Type: Personal

Contributor

  • Sponsor: United States. Department of Energy. Office of Science.
    Contributor Type: Organization
    Contributor Info: USDOE Director, Office of Science
  • Sponsor: National Institutes of Health (U.S.)
    Contributor Type: Organization

Publisher

  • Name: Lawrence Berkeley National Laboratory
    Place of Publication: Berkeley, California
    Additional Info: "Ernest Orlando Lawrence Berkeley National Laboratory, Berkeley, CA (United States)"

Date

  • Creation: 2005-12-01

Language

  • English

Description

  • Content Description: Sequence changes in regulatory regions have often been invoked to explain phenotypic divergence among species, but molecular examples of this have been difficult to obtain. In this study we identified an anthropoid primate-specific sequence element that contributed to the regulatory evolution of the low-density lipoprotein receptor. Using a combination of close and distant species genomic sequence comparisons coupled with in vivo and in vitro studies, we found that a functional cholesterol-sensing sequence motif arose and was fixed within a pre-existing enhancer in the common ancestor of anthropoid primates. Our study demonstrates one molecular mechanism by which ancestral mammalian regulatory elements can evolve to perform new functions in the primate lineage leading to human.

Subject

  • Keyword: Lipoproteins
  • Keyword: In Vitro
  • Keyword: Functionals
  • Keyword: In Vivo
  • STI Subject Categories: 60
  • Keyword: Primates

Source

  • Journal Name: Genome Biology; Journal Volume: 7; Journal Issue: 8; Related Information: Journal Publication Date: 08/02/2006

Collection

  • Name: Office of Scientific & Technical Information Technical Reports
    Code: OSTI

Institution

  • Name: UNT Libraries Government Documents Department
    Code: UNTGD

Resource Type

  • Article

Format

  • Text

Identifier

  • Report No.: LBNL--59217
  • Grant Number: DE-AC02-05CH11231
  • Office of Scientific & Technical Information Report Number: 900785
  • Archival Resource Key: ark:/67531/metadc885857