Preparation of pHEMA-CP composites with high interfacial adhesionvia template-driven mineralization

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We report a template-driven nucleation and mineral growth process for the high-affinity integration of calcium phosphate (CP) with a poly(2-hydroxyethyl methacrylate) (pHEMA) hydrogel scaffold. A mineralization technique was developed that exposes carboxylate groups on the surface of crosslinked pHEMA, promoting high-affinity nucleation and growth of calcium phosphate on the surface along with extensive calcification of the hydrogel interior. External factors such as the heating rate, the agitation of the mineral stock solution and the duration of the process that affect the outcome of the mineralization were investigated. This template-driven mineralization technique provides an efficient approach toward bonelike composites with high ... continued below

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Song, Jie; Saiz, Eduardo & Bertozzi, Carolyn R. December 5, 2002.

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We report a template-driven nucleation and mineral growth process for the high-affinity integration of calcium phosphate (CP) with a poly(2-hydroxyethyl methacrylate) (pHEMA) hydrogel scaffold. A mineralization technique was developed that exposes carboxylate groups on the surface of crosslinked pHEMA, promoting high-affinity nucleation and growth of calcium phosphate on the surface along with extensive calcification of the hydrogel interior. External factors such as the heating rate, the agitation of the mineral stock solution and the duration of the process that affect the outcome of the mineralization were investigated. This template-driven mineralization technique provides an efficient approach toward bonelike composites with high mineral-hydrogel interfacial adhesion strength.

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  • Journal Name: Journal of the European Ceramic Society; Journal Volume: 23; Journal Issue: 15; Related Information: Journal Publication Date: 2003

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  • Report No.: LBNL--52645
  • Grant Number: DE-AC02-05CH11231
  • Office of Scientific & Technical Information Report Number: 918104
  • Archival Resource Key: ark:/67531/metadc885636

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  • December 5, 2002

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  • Sept. 22, 2016, 2:13 a.m.

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  • Sept. 29, 2016, 3:53 p.m.

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Song, Jie; Saiz, Eduardo & Bertozzi, Carolyn R. Preparation of pHEMA-CP composites with high interfacial adhesionvia template-driven mineralization, article, December 5, 2002; Berkeley, California. (digital.library.unt.edu/ark:/67531/metadc885636/: accessed August 20, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.