Convergent evolution in primates and an insectivore

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The cardiovascular risk factor apolipoprotein(a) (apo(a)) has a puzzling distribution among mammals, its presence being limited to a subset of primates and a member of the insectivore lineage, the hedgehog. To explore the evolutionary history of apo(a), we performed extensive genomic sequence comparisons of multiple species with and without an apo(a) gene product, such as human, baboon, hedgehog, lemurand mouse. This analysis indicated that apo(a) arose independently in a subset of primates, including baboon and human, and an insectivore, the hedgehog, and was not simply lost by species lacking it. The similar structural domains shared by the hedgehog and primate ... continued below

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19-23

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Boffelli, Dario; Cheng, Jan-Fang & Rubin, Edward M. April 16, 2003.

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The cardiovascular risk factor apolipoprotein(a) (apo(a)) has a puzzling distribution among mammals, its presence being limited to a subset of primates and a member of the insectivore lineage, the hedgehog. To explore the evolutionary history of apo(a), we performed extensive genomic sequence comparisons of multiple species with and without an apo(a) gene product, such as human, baboon, hedgehog, lemurand mouse. This analysis indicated that apo(a) arose independently in a subset of primates, including baboon and human, and an insectivore, the hedgehog, and was not simply lost by species lacking it. The similar structural domains shared by the hedgehog and primate apo(a) indicate that they were formed by a unique molecular mechanism involving the convergent evolution of paralogous genes in these distantspecies.

Physical Description

19-23

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  • Journal Name: Genomics; Journal Volume: 83; Journal Issue: 1; Conference: 01/2004; Related Information: Journal Publication Date: 01/2004

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  • Report No.: LBNL--52679
  • Grant Number: DE-AC02-05CH11231
  • Grant Number: NIHHL66728
  • Office of Scientific & Technical Information Report Number: 917811
  • Archival Resource Key: ark:/67531/metadc884544

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Office of Scientific & Technical Information Technical Reports

Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

Office of Scientific and Technical Information (OSTI) is the Department of Energy (DOE) office that collects, preserves, and disseminates DOE-sponsored research and development (R&D) results that are the outcomes of R&D projects or other funded activities at DOE labs and facilities nationwide and grantees at universities and other institutions.

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  • April 16, 2003

Added to The UNT Digital Library

  • Sept. 22, 2016, 2:13 a.m.

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  • Dec. 13, 2016, 8:56 p.m.

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Boffelli, Dario; Cheng, Jan-Fang & Rubin, Edward M. Convergent evolution in primates and an insectivore, article, April 16, 2003; Berkeley, California. (digital.library.unt.edu/ark:/67531/metadc884544/: accessed October 21, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.