Heightened sense for sensing: recent advances in pathogen immunoassay sensing platforms

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As part of its own defense mechanism, most bacteria have developed an innate ability to enable toxic secretion to ward off potential predators or invaders. However, this naturally occurring process has been abused since over production of the bacteria's toxin molecules could render them as potential bioweapons. As these processes (also known as ''black biology'') can be clandestinely performed in a laboratory, the threat of inflicting enormous potential damage to a nation's security and economy is invariably clear and present. Thus, efficient detection of these biothreat agents in a timely and accurate manner is highly desirable. A wealth of publications ... continued below

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PDF-file: 13 pages; size: 1.2 Mbytes

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Fischer, N; Tarasow, T & Tok, J B January 9, 2007.

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Description

As part of its own defense mechanism, most bacteria have developed an innate ability to enable toxic secretion to ward off potential predators or invaders. However, this naturally occurring process has been abused since over production of the bacteria's toxin molecules could render them as potential bioweapons. As these processes (also known as ''black biology'') can be clandestinely performed in a laboratory, the threat of inflicting enormous potential damage to a nation's security and economy is invariably clear and present. Thus, efficient detection of these biothreat agents in a timely and accurate manner is highly desirable. A wealth of publications describing various pathogen immuno-sensing advances has appeared over the last few years, and it is not the intent of this review article to detail each reported approach. Instead, we aim to survey a few recent highlights in hopes of providing the reader an overall sense of the breath of these sensing systems and platforms. Antigen targets are diverse and complex as they encompass proteins, whole viruses, and bacterial spores. The signaling processes for these reported immunoassays are usually based on colorimetric, optical, or electrochemical changes. Of equal interest is the type of platform in which the immunoassay can be performed. A few platforms suitable for pathogen detection are described.

Physical Description

PDF-file: 13 pages; size: 1.2 Mbytes

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  • Journal Name: The Analyst, vol. 132, no. 2, March 1, 2007, pp. 187-191; Journal Volume: 132; Journal Issue: 2

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  • Report No.: UCRL-JRNL-227771
  • Grant Number: W-7405-ENG-48
  • Office of Scientific & Technical Information Report Number: 902317
  • Archival Resource Key: ark:/67531/metadc883231

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Office of Scientific & Technical Information Technical Reports

Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

Office of Scientific and Technical Information (OSTI) is the Department of Energy (DOE) office that collects, preserves, and disseminates DOE-sponsored research and development (R&D) results that are the outcomes of R&D projects or other funded activities at DOE labs and facilities nationwide and grantees at universities and other institutions.

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  • January 9, 2007

Added to The UNT Digital Library

  • Sept. 22, 2016, 2:13 a.m.

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  • Nov. 28, 2016, 7:48 p.m.

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Fischer, N; Tarasow, T & Tok, J B. Heightened sense for sensing: recent advances in pathogen immunoassay sensing platforms, article, January 9, 2007; Livermore, California. (digital.library.unt.edu/ark:/67531/metadc883231/: accessed April 21, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.