Primate-Specific Evolution of an LDLR Enhancer

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Sequence changes in regulatory regions have often beeninvoked to explain phenotypic divergence among species, but molecularexamples of this have been difficult to obtain. In this study, weidentified an anthropoid primate specific sequence element thatcontributed to the regulatory evolution of the LDL receptor. Using acombination of close and distant species genomic sequence comparisonscoupled with in vivo and in vitro studies, we show that a functionalcholesterol-sensing sequence motif arose and was fixed within apre-existing enhancer in the common ancestor of anthropoid primates. Ourstudy demonstrates one molecular mechanism by which ancestral mammalianregulatory elements can evolve to perform new functions in the primatelineage leading ... continued below

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Wang, Qian-fei; Prabhakar, Shyam; Wang, Qianben; Moses, Alan M.; Chanan, Sumita; Brown, Myles et al. June 28, 2006.

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Sequence changes in regulatory regions have often beeninvoked to explain phenotypic divergence among species, but molecularexamples of this have been difficult to obtain. In this study, weidentified an anthropoid primate specific sequence element thatcontributed to the regulatory evolution of the LDL receptor. Using acombination of close and distant species genomic sequence comparisonscoupled with in vivo and in vitro studies, we show that a functionalcholesterol-sensing sequence motif arose and was fixed within apre-existing enhancer in the common ancestor of anthropoid primates. Ourstudy demonstrates one molecular mechanism by which ancestral mammalianregulatory elements can evolve to perform new functions in the primatelineage leading to human.

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  • Journal Name: Genome Biology; Journal Volume: 7; Journal Issue: 8; Related Information: Journal Publication Date: 2 August2006

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  • Report No.: LBNL--61556
  • Grant Number: DE-AC02-05CH11231
  • Grant Number: NIHU1HL66681B
  • DOI: 10.1186/gb-2006-7-8-r68 | External Link
  • Office of Scientific & Technical Information Report Number: 919258
  • Archival Resource Key: ark:/67531/metadc880954

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  • June 28, 2006

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  • Sept. 22, 2016, 2:13 a.m.

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  • Oct. 3, 2017, 2:02 p.m.

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Wang, Qian-fei; Prabhakar, Shyam; Wang, Qianben; Moses, Alan M.; Chanan, Sumita; Brown, Myles et al. Primate-Specific Evolution of an LDLR Enhancer, article, June 28, 2006; Berkeley, California. (digital.library.unt.edu/ark:/67531/metadc880954/: accessed September 20, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.