Biological detection and tagging using tailorable, reactive, highly fluorescent chemosensors.

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Description

This program was focused on the development of a fluorogenic chemosensor family that could tuned for reaction with electrophilic (e.g. chemical species, toxins) and nucleophilic (e.g. proteins and other biological molecules) species. Our chemosensor approach utilized the fluorescent properties of well-known berberine-type alkaloids. In situ chemosensor reaction with a target species transformed two out-of-plane, weakly conjugated, short-wavelength chromophores into one rigid, planar, conjugated, chromophore with strong long wavelength fluorescence (530-560 nm,) and large Stokes shift (100-180 nm). The chemosensor was activated with an isourea group which allowed for reaction with carboxylic acid moieties found in amino acids.

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16 p.

Creation Information

Shepodd, Timothy J.; Zifer, Thomas; McElhanon, James Ross & Rahn, Larry A. November 1, 2006.

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Description

This program was focused on the development of a fluorogenic chemosensor family that could tuned for reaction with electrophilic (e.g. chemical species, toxins) and nucleophilic (e.g. proteins and other biological molecules) species. Our chemosensor approach utilized the fluorescent properties of well-known berberine-type alkaloids. In situ chemosensor reaction with a target species transformed two out-of-plane, weakly conjugated, short-wavelength chromophores into one rigid, planar, conjugated, chromophore with strong long wavelength fluorescence (530-560 nm,) and large Stokes shift (100-180 nm). The chemosensor was activated with an isourea group which allowed for reaction with carboxylic acid moieties found in amino acids.

Physical Description

16 p.

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  • Report No.: SAND2006-6743
  • Grant Number: AC04-94AL85000
  • DOI: 10.2172/895704 | External Link
  • Office of Scientific & Technical Information Report Number: 895704
  • Archival Resource Key: ark:/67531/metadc879362

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Office of Scientific & Technical Information Technical Reports

Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

Office of Scientific and Technical Information (OSTI) is the Department of Energy (DOE) office that collects, preserves, and disseminates DOE-sponsored research and development (R&D) results that are the outcomes of R&D projects or other funded activities at DOE labs and facilities nationwide and grantees at universities and other institutions.

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Creation Date

  • November 1, 2006

Added to The UNT Digital Library

  • Sept. 22, 2016, 2:13 a.m.

Description Last Updated

  • Nov. 22, 2016, 9:20 p.m.

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Shepodd, Timothy J.; Zifer, Thomas; McElhanon, James Ross & Rahn, Larry A. Biological detection and tagging using tailorable, reactive, highly fluorescent chemosensors., report, November 1, 2006; United States. (digital.library.unt.edu/ark:/67531/metadc879362/: accessed November 23, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.