Interspecies comparison of the tissue distribution of WR-2721, a radioprotective drug

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Pre-irradiation intravenous administration of the radioprotective drug S- 2-[3-aminopropylamino]ethylphosphorothioic acid (WR-2721) has potential value in radiotherapy because it doubles the radiation resistance of normal mouse tissues while affording only minimal protection to tumors. Deficient deposition of WR- 2721 in tumor tissue has recently been demonstrated and this is thought to be a major reason for the preferential protection of normal tissues by the drug. Data originally obtained in studies using the mouse and rat indicated that the tissue distribution of WR-2721 was possibly more closely related to dose per unit surface area than to dose per unit weight. To test ... continued below

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Pages: 6

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Washburn, L.C.; Rafter, J.J.; Hayes, R.L. & Yuhas, J.M. January 1, 1975.

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Pre-irradiation intravenous administration of the radioprotective drug S- 2-[3-aminopropylamino]ethylphosphorothioic acid (WR-2721) has potential value in radiotherapy because it doubles the radiation resistance of normal mouse tissues while affording only minimal protection to tumors. Deficient deposition of WR- 2721 in tumor tissue has recently been demonstrated and this is thought to be a major reason for the preferential protection of normal tissues by the drug. Data originally obtained in studies using the mouse and rat indicated that the tissue distribution of WR-2721 was possibly more closely related to dose per unit surface area than to dose per unit weight. To test this hypothesis an interspecies comparison of the tissue distribution of $sup 35$S-labeled WR-2721 was carried out in normal mice, rats, rabbits, and dogs at 15 and 30 minutes after intravenous administration. Results suggest that the surface area and body weight exert equal effects on the tissue concentration of WR-2721. The results further suggest that lower absolute doses of WR-2721 in the human, possibly as low as 20 mg/kg, may provide a radioprotective effect equivalent to that produced from 100 mg/kg in the mouse, i.e., a 50 to 80 percent increase in radiation resistance (CH)

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Pages: 6

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Dep. NTIS

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  • 3. annual meeting of the southeastern cancer research association, Atlanta, Georgia, USA, 2 Oct 1975

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  • Report No.: CONF-751001--4
  • Grant Number: None
  • Office of Scientific & Technical Information Report Number: 4191442
  • Archival Resource Key: ark:/67531/metadc879199

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  • January 1, 1975

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  • Sept. 21, 2016, 2:29 a.m.

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  • Oct. 20, 2016, 8:54 p.m.

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Washburn, L.C.; Rafter, J.J.; Hayes, R.L. & Yuhas, J.M. Interspecies comparison of the tissue distribution of WR-2721, a radioprotective drug, article, January 1, 1975; United States. (digital.library.unt.edu/ark:/67531/metadc879199/: accessed August 22, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.