SYNTHESIS OF PROTEINS BY NATIVE CHEMICAL LIGATION USING FMOC-BASED CHEMISTRY

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C-terminal peptide {alpha}-thioesters are valuable intermediates in the synthesis/semisynthesis of proteins by native chemical ligation. They are prepared either by solid-phase peptide synthesis (SPPS) or biosynthetically by protein splicing techniques. The present paper reviews the different methods available for the chemical synthesis of peptide {alpha}-thioesters using Fmoc-based SPPS.

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Camarero, J A & Mitchell, A R January 20, 2005.

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C-terminal peptide {alpha}-thioesters are valuable intermediates in the synthesis/semisynthesis of proteins by native chemical ligation. They are prepared either by solid-phase peptide synthesis (SPPS) or biosynthetically by protein splicing techniques. The present paper reviews the different methods available for the chemical synthesis of peptide {alpha}-thioesters using Fmoc-based SPPS.

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PDF-file: 11 pages; size: 0.5 Mbytes

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  • Journal Name: Protein and Peptide Letters; Journal Volume: 12; Journal Issue: 8

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  • Report No.: UCRL-JRNL-209192
  • Grant Number: W-7405-ENG-48
  • Office of Scientific & Technical Information Report Number: 875926
  • Archival Resource Key: ark:/67531/metadc879194

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  • January 20, 2005

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  • Sept. 21, 2016, 2:29 a.m.

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  • Dec. 8, 2016, 11:22 p.m.

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Camarero, J A & Mitchell, A R. SYNTHESIS OF PROTEINS BY NATIVE CHEMICAL LIGATION USING FMOC-BASED CHEMISTRY, article, January 20, 2005; Livermore, California. (digital.library.unt.edu/ark:/67531/metadc879194/: accessed December 17, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.