Retrospective Birth Dating of Cells

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The generation of cells in the human body has been difficult to study and our understanding of cell turnover is limited. Extensive testing of nuclear weapons resulted in a dramatic global increase in the levels of the isotope {sup 14}C in the atmosphere, followed by an exponential decrease after the test ban treaty in 1963. We show that the level of {sup 14}C in genomic DNA closely parallels atmospheric levels, and can be used to establish the time point when the DNA was synthesized and cells were born. We use this strategy to determine the age of cells in the ... continued below

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PDF-file: 41 pages; size: 1.3 Mbytes

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L.Spalding, K; Bhardwaj, R D; Buchholz, B A; Druid, H & Frisen, J April 19, 2005.

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The generation of cells in the human body has been difficult to study and our understanding of cell turnover is limited. Extensive testing of nuclear weapons resulted in a dramatic global increase in the levels of the isotope {sup 14}C in the atmosphere, followed by an exponential decrease after the test ban treaty in 1963. We show that the level of {sup 14}C in genomic DNA closely parallels atmospheric levels, and can be used to establish the time point when the DNA was synthesized and cells were born. We use this strategy to determine the age of cells in the cortex of the adult human brain, and show that whereas non-neuronal cells are exchanged, occipital neurons are as old as the individual, supporting the view that postnatal neurogenesis does not take place in this region. Retrospective birth dating is a generally applicable strategy that can be used to measure cell turnover in man under physiological and pathological conditions.

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PDF-file: 41 pages; size: 1.3 Mbytes

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  • Journal Name: Cell; Journal Volume: 122; Journal Issue: 10

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  • Report No.: UCRL-JRNL-211546
  • Grant Number: W-7405-ENG-48
  • Office of Scientific & Technical Information Report Number: 877846
  • Archival Resource Key: ark:/67531/metadc877713

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Office of Scientific & Technical Information Technical Reports

Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

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  • April 19, 2005

Added to The UNT Digital Library

  • Sept. 21, 2016, 2:29 a.m.

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  • Dec. 7, 2016, 8:37 p.m.

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L.Spalding, K; Bhardwaj, R D; Buchholz, B A; Druid, H & Frisen, J. Retrospective Birth Dating of Cells, article, April 19, 2005; Livermore, California. (digital.library.unt.edu/ark:/67531/metadc877713/: accessed June 18, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.