A common allele on chromosome 9 associated with coronary heartdisease

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Coronary heart disease (CHD) is a major cause of death in Western countries. Here we used genome-wide association scanning to identify a 58 kb interval on chromosome 9 that was consistently associated with CHD in six independent samples. The interval contains no annotated genes and is not associated with established CHD risk factors such as plasma lipoproteins, hypertension or diabetes. Homozygotes for the risk allele comprise 20-25% of Caucasians and have a {approx}30-40% increased risk of CHD. These data indicate that the susceptibility allele acts through a novel mechanism to increase CHD risk in a large fraction of the population.

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McPherson, Ruth; Pertsemlidis, Alexander; Kavaslar, Nihan; Stewart, Alexandre; Roberts, Robert; Cox, David R. et al. March 1, 2007.

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Description

Coronary heart disease (CHD) is a major cause of death in Western countries. Here we used genome-wide association scanning to identify a 58 kb interval on chromosome 9 that was consistently associated with CHD in six independent samples. The interval contains no annotated genes and is not associated with established CHD risk factors such as plasma lipoproteins, hypertension or diabetes. Homozygotes for the risk allele comprise 20-25% of Caucasians and have a {approx}30-40% increased risk of CHD. These data indicate that the susceptibility allele acts through a novel mechanism to increase CHD risk in a large fraction of the population.

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  • Journal Name: Science; Journal Volume: 316; Related Information: Journal Publication Date: 06/08/2007

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  • Report No.: LBNL--62782
  • Grant Number: DE-AC02-05CH11231
  • DOI: 10.1126/science.1142447 | External Link
  • Office of Scientific & Technical Information Report Number: 910328
  • Archival Resource Key: ark:/67531/metadc877413

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Office of Scientific & Technical Information Technical Reports

Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

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  • March 1, 2007

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  • Sept. 22, 2016, 2:13 a.m.

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McPherson, Ruth; Pertsemlidis, Alexander; Kavaslar, Nihan; Stewart, Alexandre; Roberts, Robert; Cox, David R. et al. A common allele on chromosome 9 associated with coronary heartdisease, article, March 1, 2007; United States. (digital.library.unt.edu/ark:/67531/metadc877413/: accessed December 12, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.