Bioagent Sample Matching using Elemental Composition Data: an Approach to Validation

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Sample matching is a fundamental capability that can have high probative value in a forensic context if proper validation studies are performed. In this report we discuss the potential utility of using the elemental composition of two bioagent samples to decide if they were produced in the same batch, or by the same process. Using guidance from the recent NRC study of bullet lead analysis and other sources, we develop a basic likelihood ratio framework for evaluating the evidentiary weight of elemental analysis data for sample matching. We define an objective metric for comparing two samples, and propose a method ... continued below

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PDF-file: 43 pages; size: 0.7 Mbytes

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Velsko, S P April 21, 2006.

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Description

Sample matching is a fundamental capability that can have high probative value in a forensic context if proper validation studies are performed. In this report we discuss the potential utility of using the elemental composition of two bioagent samples to decide if they were produced in the same batch, or by the same process. Using guidance from the recent NRC study of bullet lead analysis and other sources, we develop a basic likelihood ratio framework for evaluating the evidentiary weight of elemental analysis data for sample matching. We define an objective metric for comparing two samples, and propose a method for constructing an unbiased population of test samples. We illustrate the basic methodology with some existing data on dry Bacillus thuringiensis preparations, and outline a comprehensive plan for experimental validation of this approach.

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PDF-file: 43 pages; size: 0.7 Mbytes

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  • Report No.: UCRL-TR-220803
  • Grant Number: W-7405-ENG-48
  • DOI: 10.2172/899392 | External Link
  • Office of Scientific & Technical Information Report Number: 899392
  • Archival Resource Key: ark:/67531/metadc877218

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Office of Scientific & Technical Information Technical Reports

Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

Office of Scientific and Technical Information (OSTI) is the Department of Energy (DOE) office that collects, preserves, and disseminates DOE-sponsored research and development (R&D) results that are the outcomes of R&D projects or other funded activities at DOE labs and facilities nationwide and grantees at universities and other institutions.

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  • April 21, 2006

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  • Sept. 22, 2016, 2:13 a.m.

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  • Dec. 9, 2016, 3:28 p.m.

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Velsko, S P. Bioagent Sample Matching using Elemental Composition Data: an Approach to Validation, report, April 21, 2006; Livermore, California. (digital.library.unt.edu/ark:/67531/metadc877218/: accessed April 25, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.