The Pathogenomic Sequence Analysis of B. cereus and B. Thuringiensis isolates closely related to Bacillus anthracis

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The sequencing and analysis of two close relatives of Bacillus anthracis are reported. AFLP analysis of over 300 isolates of B. cereus, B. thuringiensis and B. anthracis identified two isolates as being very closely related to B. anthracis. One, a B. cereus, BcE33L, was isolated from a zebra carcass in Nambia; the second, a B. thuringiensis, 97-27, was isolated from a necrotic human wound. The B. cereus appears to be the closest anthracis relative sequenced to date. A core genome of over 3,900 genes was compiled for the Bacillus cereus group, including B anthracis. Comparative analysis of these two genomes ... continued below

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Han, C S; Xie, G; Challacombe, J F; Altherr, M R; Bhotika, S S; Bruce, D et al. October 12, 2005.

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The sequencing and analysis of two close relatives of Bacillus anthracis are reported. AFLP analysis of over 300 isolates of B. cereus, B. thuringiensis and B. anthracis identified two isolates as being very closely related to B. anthracis. One, a B. cereus, BcE33L, was isolated from a zebra carcass in Nambia; the second, a B. thuringiensis, 97-27, was isolated from a necrotic human wound. The B. cereus appears to be the closest anthracis relative sequenced to date. A core genome of over 3,900 genes was compiled for the Bacillus cereus group, including B anthracis. Comparative analysis of these two genomes with other members of the B. cereus group provides insight into the evolutionary relationships among these organisms. Evidence is presented that differential regulation modulates virulence, rather than simple acquisition of virulence factors. These genome sequences provide insight into the molecular mechanisms contributing to the host range and virulence of this group of organisms.

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PDF-file: 49 pages; size: 0 Kbytes

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  • Journal Name: Journal of Bacteriology; Journal Volume: 180; Journal Issue: 9

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  • Report No.: UCRL-JRNL-216210
  • Grant Number: W-7405-ENG-48
  • Office of Scientific & Technical Information Report Number: 885390
  • Archival Resource Key: ark:/67531/metadc875986

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  • October 12, 2005

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  • Sept. 21, 2016, 2:29 a.m.

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  • Nov. 30, 2016, 4:14 p.m.

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Han, C S; Xie, G; Challacombe, J F; Altherr, M R; Bhotika, S S; Bruce, D et al. The Pathogenomic Sequence Analysis of B. cereus and B. Thuringiensis isolates closely related to Bacillus anthracis, article, October 12, 2005; Livermore, California. (digital.library.unt.edu/ark:/67531/metadc875986/: accessed December 16, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.