In-vivo imaging of the photoreceptor mosaic in retinal dystrophies and correlations with visual function

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To relate in-vivo microscopic retinal changes to visual function assessed with clinical tests in patients with various forms of retinal dystrophies. The UC Davis Adaptive Optics (AO) Fundus Camera was used to acquire in-vivo retinal images at the cellular level. Visual function tests, consisting of visual field analysis, multifocal electroretinography (mfERG), contrast sensitivity and color vision measures, were performed on all subjects. Five patients with different forms of retinal dystrophies and three control subjects were recruited. Cone densities were quantified for all retinal images. In all images of diseased retinas, there were extensive areas of dark space between groups of ... continued below

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Choi, S; Doble, N; Hardy, J; Jones, S; Keltner, J; Olivier, S et al. October 26, 2005.

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Description

To relate in-vivo microscopic retinal changes to visual function assessed with clinical tests in patients with various forms of retinal dystrophies. The UC Davis Adaptive Optics (AO) Fundus Camera was used to acquire in-vivo retinal images at the cellular level. Visual function tests, consisting of visual field analysis, multifocal electroretinography (mfERG), contrast sensitivity and color vision measures, were performed on all subjects. Five patients with different forms of retinal dystrophies and three control subjects were recruited. Cone densities were quantified for all retinal images. In all images of diseased retinas, there were extensive areas of dark space between groups of photoreceptors, where no cone photoreceptors were evident. These irregular features were not seen in healthy retinas, but were characteristic features in fundi with retinal dystrophies. There was a correlation between functional vision loss and the extent to which the irregularities occurred in retinal images. Cone densities were found to decrease with an associated decrease in retinal function. AO fundus photography is a reliable technique for assessing and quantifying the changes in the photoreceptor layer as disease progresses. Furthermore, this technique can be useful in cases where visual function tests give borderline or ambiguous results, as it allows visualization of individual photoreceptors.

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PDF-file: 39 pages; size: 0 Kbytes

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  • Report No.: UCRL-TR-216589
  • Grant Number: W-7405-ENG-48
  • DOI: 10.2172/886664 | External Link
  • Office of Scientific & Technical Information Report Number: 886664
  • Archival Resource Key: ark:/67531/metadc875464

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Office of Scientific & Technical Information Technical Reports

Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

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  • October 26, 2005

Added to The UNT Digital Library

  • Sept. 21, 2016, 2:29 a.m.

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  • Nov. 29, 2016, 2:54 p.m.

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Choi, S; Doble, N; Hardy, J; Jones, S; Keltner, J; Olivier, S et al. In-vivo imaging of the photoreceptor mosaic in retinal dystrophies and correlations with visual function, report, October 26, 2005; Livermore, California. (digital.library.unt.edu/ark:/67531/metadc875464/: accessed November 17, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.