The genome of obligately intracellular Ehrlichia canis revealsthemes of complex membrane structure and immune evasion strategies

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Ehrlichia canis, a small obligately intracellular, tick-transmitted, gram-negative, a-proteobacterium is the primary etiologic agent of globally distributed canine monocytic ehrlichiosis. Complete genome sequencing revealed that the E. canis genome consists of a single circular chromosome of 1,315,030 bp predicted to encode 925 proteins, 40 stable RNA species, and 17 putative pseudogenes, and a substantial proportion of non-coding sequence (27 percent). Interesting genome features include a large set of proteins with transmembrane helices and/or signal sequences, and a unique serine-threonine bias associated with the potential for O-glycosylation that was prominent in proteins associated with pathogen-host interactions. Furthermore, two paralogous protein families ... continued below

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Mavromatis, K.; Kuyler Doyle, C.; Lykidis, A.; Ivanova, N.; Francino, P.; Chain, P. et al. September 1, 2005.

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Ehrlichia canis, a small obligately intracellular, tick-transmitted, gram-negative, a-proteobacterium is the primary etiologic agent of globally distributed canine monocytic ehrlichiosis. Complete genome sequencing revealed that the E. canis genome consists of a single circular chromosome of 1,315,030 bp predicted to encode 925 proteins, 40 stable RNA species, and 17 putative pseudogenes, and a substantial proportion of non-coding sequence (27 percent). Interesting genome features include a large set of proteins with transmembrane helices and/or signal sequences, and a unique serine-threonine bias associated with the potential for O-glycosylation that was prominent in proteins associated with pathogen-host interactions. Furthermore, two paralogous protein families associated with immune evasion were identified, one of which contains poly G:C tracts, suggesting that they may play a role in phase variation and facilitation of persistent infections. Proteins associated with pathogen-host interactions were identified including a small group of proteins (12) with tandem repeats and another with eukaryotic-like ankyrin domains (7).

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  • Journal Name: Journal of Bacteriology; Journal Volume: 188; Journal Issue: 11; Related Information: Journal Publication Date: 06/2006

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  • Report No.: LBNL--58778
  • Grant Number: DE-AC02-05CH11231
  • Office of Scientific & Technical Information Report Number: 887440
  • Archival Resource Key: ark:/67531/metadc875018

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  • September 1, 2005

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  • Sept. 21, 2016, 2:29 a.m.

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  • Sept. 29, 2016, 2:46 p.m.

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Mavromatis, K.; Kuyler Doyle, C.; Lykidis, A.; Ivanova, N.; Francino, P.; Chain, P. et al. The genome of obligately intracellular Ehrlichia canis revealsthemes of complex membrane structure and immune evasion strategies, article, September 1, 2005; Berkeley, California. (digital.library.unt.edu/ark:/67531/metadc875018/: accessed August 17, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.