EXPRESSED PROTEIN LIGATION. A NEW TOOL FOR THE BIOSYNTHESIS OF CYCLIC POLYPEPTIDES

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The present paper reviews the use of expressed protein ligation for the biosynthesis of backbone cyclic polypeptides. This general method allows the in vivo and in vitro biosynthesis of cyclic polypeptides using recombinant DNA expression techniques. Biosynthetic access to backbone cyclic peptides opens the possibility to generate cell-based combinatorial libraries that can be screened inside living cells for their ability to attenuate or inhibit cellular processes.

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Kimura, R & Camarero, J A November 11, 2004.

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The present paper reviews the use of expressed protein ligation for the biosynthesis of backbone cyclic polypeptides. This general method allows the in vivo and in vitro biosynthesis of cyclic polypeptides using recombinant DNA expression techniques. Biosynthetic access to backbone cyclic peptides opens the possibility to generate cell-based combinatorial libraries that can be screened inside living cells for their ability to attenuate or inhibit cellular processes.

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PDF-file: 12 pages; size: 0.7 Mbytes

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  • Journal Name: Protein and Peptide Letters; Journal Volume: 12; Journal Issue: 8

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  • Report No.: UCRL-JRNL-208023
  • Grant Number: W-7405-ENG-48
  • Office of Scientific & Technical Information Report Number: 877860
  • Archival Resource Key: ark:/67531/metadc874396

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  • November 11, 2004

Added to The UNT Digital Library

  • Sept. 21, 2016, 2:29 a.m.

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  • Nov. 28, 2016, 2:35 p.m.

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Kimura, R & Camarero, J A. EXPRESSED PROTEIN LIGATION. A NEW TOOL FOR THE BIOSYNTHESIS OF CYCLIC POLYPEPTIDES, article, November 11, 2004; Livermore, California. (digital.library.unt.edu/ark:/67531/metadc874396/: accessed November 18, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.