Unusual Gene Order and Organization of the Sea Urchin Hox Cluster

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The highly consistent gene order and axial colinear expression patterns found in vertebrate hox gene clusters are less well conserved across the rest of bilaterians. We report the first deuterostome instance of an intact hox cluster with a unique gene order where the paralog groups are not expressed in a sequential manner. The finished sequence from BAC clones from the genome of the sea urchin, Strongylocentrotus purpuratus, reveals a gene order wherein the anterior genes (Hox1, Hox2 and Hox3) lie nearest the posterior genes in the cluster such that the most 3 gene is Hox5. (The gene order is : ... continued below

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PDF-file: 28 pages; size: 1.8 Mbytes

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Cameron, R A; Rowen, L; Nesbitt, R; Bloom, S; Rast, J P; Berney, K et al. October 11, 2005.

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The highly consistent gene order and axial colinear expression patterns found in vertebrate hox gene clusters are less well conserved across the rest of bilaterians. We report the first deuterostome instance of an intact hox cluster with a unique gene order where the paralog groups are not expressed in a sequential manner. The finished sequence from BAC clones from the genome of the sea urchin, Strongylocentrotus purpuratus, reveals a gene order wherein the anterior genes (Hox1, Hox2 and Hox3) lie nearest the posterior genes in the cluster such that the most 3 gene is Hox5. (The gene order is : 5-Hox1, 2, 3, 11/13c, 11/13b, 11/13a, 9/10, 8, 7, 6, 5 - 3). The finished sequence result is corroborated by restriction mapping evidence and BAC-end scaffold analyses. Comparisons with a putative ancestral deuterostome Hox gene cluster suggest that the rearrangements leading to the sea urchin gene order were many and complex.

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PDF-file: 28 pages; size: 1.8 Mbytes

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  • Journal Name: Journal of Experimental Zoology Part B: Molecular and Developmental Evolution; Journal Volume: 306B; Journal Issue: 1

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  • Report No.: UCRL-JRNL-216151
  • Grant Number: W-7405-ENG-48
  • Office of Scientific & Technical Information Report Number: 877934
  • Archival Resource Key: ark:/67531/metadc873284

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  • October 11, 2005

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  • Sept. 21, 2016, 2:29 a.m.

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  • Dec. 2, 2016, 5:04 p.m.

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Cameron, R A; Rowen, L; Nesbitt, R; Bloom, S; Rast, J P; Berney, K et al. Unusual Gene Order and Organization of the Sea Urchin Hox Cluster, article, October 11, 2005; Livermore, California. (digital.library.unt.edu/ark:/67531/metadc873284/: accessed September 22, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.