Molecular dosimetry of chemical mutagens: measurement of molecular dose and DNA repair germ cells

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Molecular dosimetry in the germ cells of male mice is reviewed with regard to in vivo alkylation of sperm heads, in vivo alkylation of sperm DNA, and possible alkylation of sperm protamine. DNA repair in male germ cells is reviewed with regard to basic design of experiments, DNA repair in various stages of spermatogenesis, effect of protamine on DNA repair following treatment with EMS or x radiation, and induction of DNA repair by methyl methanesulfonate, propyl methanesulfonate, and isopropyl methanesulfonate. (HLW)

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21 p.

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Sega, G.A. January 1, 1975.

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Molecular dosimetry in the germ cells of male mice is reviewed with regard to in vivo alkylation of sperm heads, in vivo alkylation of sperm DNA, and possible alkylation of sperm protamine. DNA repair in male germ cells is reviewed with regard to basic design of experiments, DNA repair in various stages of spermatogenesis, effect of protamine on DNA repair following treatment with EMS or x radiation, and induction of DNA repair by methyl methanesulfonate, propyl methanesulfonate, and isopropyl methanesulfonate. (HLW)

Physical Description

21 p.

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Dep. NTIS

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  • 6. annual meeting of the environmental Mutagen Society, Miami Beach, Florida, USA, 9 May 1975

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  • Report No.: CONF-750571--1
  • Grant Number: None
  • Office of Scientific & Technical Information Report Number: 4145295
  • Archival Resource Key: ark:/67531/metadc870855

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Office of Scientific & Technical Information Technical Reports

Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

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  • January 1, 1975

Added to The UNT Digital Library

  • Sept. 16, 2016, 12:32 a.m.

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  • Oct. 12, 2017, 4:38 p.m.

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Sega, G.A. Molecular dosimetry of chemical mutagens: measurement of molecular dose and DNA repair germ cells, article, January 1, 1975; Tennessee. (digital.library.unt.edu/ark:/67531/metadc870855/: accessed December 18, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.