Genetic and hematopoietic effects of long-term tritiated water (HTO) ingestion in mice

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The positive effects seen using the somewhat insensitive dominant lethal test system and the effects seen on the blood-forming cells indicates that at least in the mouse there is a hazard in the continuous ingestion of HTO at a concentration of 3 $mu$CCi/ml. A direct comparison of these results to the human drinking an equivalent amount of HTO is impossible due to the obvious differences in water metabolism between the two species. Until further experimentation at lower levels of ingestion are completed, it is difficult to comment concerning the significance of these results as related to current concepts of maximum ... continued below

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12 p.

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Carsten, A.L. & Cronkite, E.P. January 1, 1975.

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Description

The positive effects seen using the somewhat insensitive dominant lethal test system and the effects seen on the blood-forming cells indicates that at least in the mouse there is a hazard in the continuous ingestion of HTO at a concentration of 3 $mu$CCi/ml. A direct comparison of these results to the human drinking an equivalent amount of HTO is impossible due to the obvious differences in water metabolism between the two species. Until further experimentation at lower levels of ingestion are completed, it is difficult to comment concerning the significance of these results as related to current concepts of maximum permissible concentration. Studies are now underway examining the possible effects of lower concentrations of chronic HTO ingestion. (auth)

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12 p.

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Dep. NTIS

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  • IAEA international symposium on biological effects of low level radiation pertinent to protection of man and his environment, Chicago, Illinois, USA, 3 Nov 1975

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  • Report No.: BNL--20599
  • Report No.: CONF-751126--7
  • Report No.: SM--202/303
  • Grant Number: None
  • Office of Scientific & Technical Information Report Number: 4160979
  • Archival Resource Key: ark:/67531/metadc870800

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Office of Scientific & Technical Information Technical Reports

Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

Office of Scientific and Technical Information (OSTI) is the Department of Energy (DOE) office that collects, preserves, and disseminates DOE-sponsored research and development (R&D) results that are the outcomes of R&D projects or other funded activities at DOE labs and facilities nationwide and grantees at universities and other institutions.

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  • January 1, 1975

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  • Sept. 16, 2016, 12:32 a.m.

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  • Oct. 11, 2017, 3:26 p.m.

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Carsten, A.L. & Cronkite, E.P. Genetic and hematopoietic effects of long-term tritiated water (HTO) ingestion in mice, article, January 1, 1975; Upton, New York. (digital.library.unt.edu/ark:/67531/metadc870800/: accessed December 17, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.