Cerebral imaging using $sup 68$Ga DTPA and the U.C.S.F. multiwire proportional chamber positron camera

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A multiwire proportional chamber positron camera consisting of four 48 x 48 cm$sup 2$ detectors linked to a small digital computer has been designed, constructed, and characterized. Initial clinical application to brain imaging using $sup 68$Ga DTPA in 10 patients with brain tumors is described. Tomographic image reconstruction is accomplished by an algorithm determining the intersection of the annihilation photon paths in planes of interest. Final image processing utilizes uniformity correction, simple thresholding, and smoothing. The positron brain images were compared to conventional scintillation brain scans and x-ray computerized axial tomograms (CAT) in each case. The positron studies have shown ... continued below

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12 p.

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Hattner, R.S.; Lim, C.B.; Swann, S.J.; Kaufman, L.; Perez-Mendez, V.; Chu, D. et al. December 1, 1975.

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A multiwire proportional chamber positron camera consisting of four 48 x 48 cm$sup 2$ detectors linked to a small digital computer has been designed, constructed, and characterized. Initial clinical application to brain imaging using $sup 68$Ga DTPA in 10 patients with brain tumors is described. Tomographic image reconstruction is accomplished by an algorithm determining the intersection of the annihilation photon paths in planes of interest. Final image processing utilizes uniformity correction, simple thresholding, and smoothing. The positron brain images were compared to conventional scintillation brain scans and x-ray computerized axial tomograms (CAT) in each case. The positron studies have shown significant mitigation of confusing superficial activity resulting from craniotomy in comparison to conventional brain scans. Central necrosis of lesions observed in the positron images, but not in the conventional scans, has been confirmed in CAT. Modifications of the camera are being implemented to improve image quality, and these changes combined with the tomography inherent in the positron scans are anticipated to result in images superior in information content to conventional brain scans. (auth)

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12 p.

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Dep. NTIS

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  • Nuclear science symposium, San Francisco, California, USA, 17 Nov 1975

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  • Report No.: LBL--4633
  • Report No.: CONF-751116--34
  • Grant Number: W-7405-ENG-48
  • Office of Scientific & Technical Information Report Number: 4019502
  • Archival Resource Key: ark:/67531/metadc869942

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  • December 1, 1975

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  • Sept. 16, 2016, 12:32 a.m.

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  • Oct. 11, 2017, 3:24 p.m.

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Hattner, R.S.; Lim, C.B.; Swann, S.J.; Kaufman, L.; Perez-Mendez, V.; Chu, D. et al. Cerebral imaging using $sup 68$Ga DTPA and the U.C.S.F. multiwire proportional chamber positron camera, article, December 1, 1975; Berkeley, California. (digital.library.unt.edu/ark:/67531/metadc869942/: accessed October 19, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.