Leukemogenesis by low-level radiation

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Intermittent x-radiation administered in three R doses for ten successive weeks to RAP mice did not increase the incidence of leukemia. A total dose of 100 R (10 R weekly) significantly increased the level. A total dose of 300 R (30 R weekly) increased the incidence of leukemia only slightly but not significantly over that induced by the 100 R total dose. The two leukemogenic doses of x-radiation (100 and 300 R) yielded incidences of leukemia comparable to those following mean doses of perinatal gamma exposure at 200 and 1000 rads. However, continuous lifetime exposure of five successive generations to ... continued below

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Pages: 25

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Warren, S. & Gates, O. January 1, 1975.

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Description

Intermittent x-radiation administered in three R doses for ten successive weeks to RAP mice did not increase the incidence of leukemia. A total dose of 100 R (10 R weekly) significantly increased the level. A total dose of 300 R (30 R weekly) increased the incidence of leukemia only slightly but not significantly over that induced by the 100 R total dose. The two leukemogenic doses of x-radiation (100 and 300 R) yielded incidences of leukemia comparable to those following mean doses of perinatal gamma exposure at 200 and 1000 rads. However, continuous lifetime exposure of five successive generations to 30 rads was by far more effective than the higher doses of gamma or x-radiation. In these wide discrepancies between leukemogenic effects of equal low doses of gamma and x-radiation, there are two disparate factors; chronic versus intermittent exposure and the populations at risk; young adult mice versus mice exposed from conception to death. (auth)

Physical Description

Pages: 25

Notes

Dep. NTIS

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  • Other Information: Orig. Receipt Date: 30-JUN-76

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  • Report No.: COO--3017-24
  • Report No.: SM--202/218
  • Grant Number: None
  • DOI: 10.2172/4182601 | External Link
  • Office of Scientific & Technical Information Report Number: 4182601
  • Archival Resource Key: ark:/67531/metadc867321

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Office of Scientific & Technical Information Technical Reports

Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

Office of Scientific and Technical Information (OSTI) is the Department of Energy (DOE) office that collects, preserves, and disseminates DOE-sponsored research and development (R&D) results that are the outcomes of R&D projects or other funded activities at DOE labs and facilities nationwide and grantees at universities and other institutions.

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  • January 1, 1975

Added to The UNT Digital Library

  • Sept. 16, 2016, 12:32 a.m.

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Warren, S. & Gates, O. Leukemogenesis by low-level radiation, report, January 1, 1975; United States. (digital.library.unt.edu/ark:/67531/metadc867321/: accessed November 22, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.