Preparation of $sup 80$Br or $sup 82$Br-biomolecules via excitation labelling methods

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The direct decay-induced $sup 82$Br (or $sup 80$Br) labelling by exposing the solid substrate molecules, such as deoxyuridine, L-tyrosine, guanosine, deoxycytidine, phenylalanine, and acetic acid, to gaseous CF$sub 3$$sup 82$/sup m/Br (or CF$sub 3$$sup 80$/sup m/Br) was studied. The radiochemical yields of the brominated products are relatively small and range from 1 percent in the case of bromo deoxyuridine to 11 percent for bromoacetic acid. The modification of this technique by adding Cl$sub 2$ gas to the reaction mixture improves the yields in several cases drastically (up to 80 percent for bromo-guanosine and bromo-L-tyrosine). Similar improvement can be achieved by ... continued below

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Pages: 22

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Wong, S. & Ache, H.J. January 1, 1975.

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Description

The direct decay-induced $sup 82$Br (or $sup 80$Br) labelling by exposing the solid substrate molecules, such as deoxyuridine, L-tyrosine, guanosine, deoxycytidine, phenylalanine, and acetic acid, to gaseous CF$sub 3$$sup 82$/sup m/Br (or CF$sub 3$$sup 80$/sup m/Br) was studied. The radiochemical yields of the brominated products are relatively small and range from 1 percent in the case of bromo deoxyuridine to 11 percent for bromoacetic acid. The modification of this technique by adding Cl$sub 2$ gas to the reaction mixture improves the yields in several cases drastically (up to 80 percent for bromo-guanosine and bromo-L-tyrosine). Similar improvement can be achieved by exposing crystalline KBrO$sub 3$ for some time to CF$sub 3$$sup 82$/sup m/Br (or CF$sub 3$$sup 80$/sup m/Br) and dissolving subsequently the KBrO$sub 3$ in an acidic solution of the substrate. (auth)

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Pages: 22

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Dep. NTIS

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  • 169. national meeting, American Chemical Society, Philadelphia, Pennsylvania, USA, 6 Apr 1975

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  • Report No.: CONF-750410--10
  • Grant Number: None
  • Office of Scientific & Technical Information Report Number: 4166084
  • Archival Resource Key: ark:/67531/metadc866434

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Office of Scientific & Technical Information Technical Reports

Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

Office of Scientific and Technical Information (OSTI) is the Department of Energy (DOE) office that collects, preserves, and disseminates DOE-sponsored research and development (R&D) results that are the outcomes of R&D projects or other funded activities at DOE labs and facilities nationwide and grantees at universities and other institutions.

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  • January 1, 1975

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  • Sept. 16, 2016, 12:32 a.m.

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Wong, S. & Ache, H.J. Preparation of $sup 80$Br or $sup 82$Br-biomolecules via excitation labelling methods, article, January 1, 1975; United States. (digital.library.unt.edu/ark:/67531/metadc866434/: accessed December 14, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.