Progressive Epithelial Dysplasia in Mouse Skin Irradiated With 10 Mev Protons

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Up to 6 months after proton irradiation at 600 and 1200 rad epithelial hyperplasia persisted in the exposed mouse skin. Hydropic degeneration of mandy epithelial cells occurred with intra-epithelial cyst formation with hemorrhage. Focal areas of basement membrane degenerated. Interruption of and fragmentation of underlying collagen fibers was prominent. Of interest is the paramount observation that with this degree of cellular alteration and with complete breakdown of basement membrane the epithelial cells did not invade into the dermis. This suggests that the sltered epithelial cells must actually be definitely neoplastic for true invasion to occur and that a single exposure ... continued below

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15 p.

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Lippincott, S. W.; Jesseph, J. E.; Calvo, W. G. & Baker, C. P. January 1, 1961.

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Description

Up to 6 months after proton irradiation at 600 and 1200 rad epithelial hyperplasia persisted in the exposed mouse skin. Hydropic degeneration of mandy epithelial cells occurred with intra-epithelial cyst formation with hemorrhage. Focal areas of basement membrane degenerated. Interruption of and fragmentation of underlying collagen fibers was prominent. Of interest is the paramount observation that with this degree of cellular alteration and with complete breakdown of basement membrane the epithelial cells did not invade into the dermis. This suggests that the sltered epithelial cells must actually be definitely neoplastic for true invasion to occur and that a single exposure at these doses did not alter the cells sufficiently to render then andaplastic. It is possible however that larger single doses with subsequent time interval elapse might provoke the formation of neoplastic cells. This and the effect of repeated small doses and with longer periods after irradiation before sacrifice of the animal are now being investigated. (auth)

Physical Description

15 p.

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  • Other Information: From International Atomic Energy Agency Symposium on the Biological Effects of Neutron Irradiations, Upton, N.Y., Oct. 1963. Orig. Receipt Date: 31-DEC-64

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  • Report No.: BNL-7359
  • Report No.: CONF-205-8
  • Grant Number: AT(30-2)-GEN-16
  • DOI: 10.2172/4151684 | External Link
  • Office of Scientific & Technical Information Report Number: 4151684
  • Archival Resource Key: ark:/67531/metadc863890

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  • January 1, 1961

Added to The UNT Digital Library

  • Sept. 16, 2016, 12:32 a.m.

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  • Oct. 12, 2017, 1:09 p.m.

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Lippincott, S. W.; Jesseph, J. E.; Calvo, W. G. & Baker, C. P. Progressive Epithelial Dysplasia in Mouse Skin Irradiated With 10 Mev Protons, report, January 1, 1961; Upton, New York. (digital.library.unt.edu/ark:/67531/metadc863890/: accessed July 16, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.