Labeling pharmaceuticals with radioactive isotopes. Annual progress report, December 1, 1975--November 30, 1976

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Progress is reported in studies on the synthesis of $gamma$-emitting analogs of aliphatic amino acids which may be clinically useful for the localization of pancreas. The $gamma$ radionuclides to be incorporated include $sup 131$I, $sup 123$I, and $sup 77$Br. Preparation of $beta$-chloro-$alpha$- aminobutyric acid which on interchange with $sup 131$I would yield I-for-methyl analog of valine is reported. This interchange is being currently studied. The bromo derivative was also prepared and should be a more reactive substrate for halogen interchange reactions or direct isotope exchange with $sup 77$Br. Concurrently, the synthesis of the I-formethyl analog of leucine is underway. In ... continued below

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8 p.

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Blau, M. & Bender, M.A. January 1, 1976.

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Description

Progress is reported in studies on the synthesis of $gamma$-emitting analogs of aliphatic amino acids which may be clinically useful for the localization of pancreas. The $gamma$ radionuclides to be incorporated include $sup 131$I, $sup 123$I, and $sup 77$Br. Preparation of $beta$-chloro-$alpha$- aminobutyric acid which on interchange with $sup 131$I would yield I-for-methyl analog of valine is reported. This interchange is being currently studied. The bromo derivative was also prepared and should be a more reactive substrate for halogen interchange reactions or direct isotope exchange with $sup 77$Br. Concurrently, the synthesis of the I-formethyl analog of leucine is underway. In this connection, two intermediates were prepared, namely, allyl glycine and $alpha$-amino-$gamma$-valeralactone . HCl. (auth)

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8 p.

Notes

Dep. NTIS

Source

  • Other Information: Orig. Receipt Date: 30-JUN-76

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  • Report No.: COO--2361-3
  • Grant Number: AT(11-1)-2361
  • DOI: 10.2172/4051346 | External Link
  • Office of Scientific & Technical Information Report Number: 4051346
  • Archival Resource Key: ark:/67531/metadc863504

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Office of Scientific & Technical Information Technical Reports

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  • January 1, 1976

Added to The UNT Digital Library

  • Sept. 16, 2016, 12:32 a.m.

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  • Oct. 11, 2017, 2:36 p.m.

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Blau, M. & Bender, M.A. Labeling pharmaceuticals with radioactive isotopes. Annual progress report, December 1, 1975--November 30, 1976, report, January 1, 1976; United States. (digital.library.unt.edu/ark:/67531/metadc863504/: accessed November 20, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.